lesson 9 pharmacology involving infections Flashcards

1
Q

gram positive bacteria

A

remains purple ( crystal violet)

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2
Q

gram negative bacteria

A

remains red (safranin)

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3
Q

bactericidal chemo

A

kills bacteria

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4
Q

bacteriostatic chemo

A

inhibits growth of bacteria

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5
Q

antibiotics

A

chemical substances obtained from microorganisms

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6
Q

antimicrobials

A

chemical substance obtained by synthesis

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7
Q

antibacterial spectrum

A

-spectrum of bacteria susceptible to an antibiotic

effective against a wide range of bacteria

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8
Q

broad spectrum antibiotic

A

-effective against a wide range of bacteria

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9
Q

penicillin MOA + origin

A
  • obtained from mold
  • bactericidal
  • disrupts cell wall synthesis which kills the cell
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10
Q

cephalosporins MOA + generations + whats drug does this drug substitute and why?

A
  • disrupts cell wall synthesis
  • bactericidal
  • 4 generations
  • substitute for penicillin when allergy
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11
Q

cephalosporins adverse effects

A
  • GI disturbances
  • nephrotoxicity
  • doesn’t react with alcohol
  • allergy
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12
Q

aminoglycosides

A
  • gram negative
  • bacteriostatic
  • stops bacteria from synthesizing
  • poorly absorbed in GI tract
  • good for abdominal surgeries
  • IV
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13
Q

tetracylines

A
  • broad spectrum antibiotics
  • bacteriostatic
  • gram positive/negative
  • used for MRSA (tigecycline ask active/treated)
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14
Q

macroline antibiotics

A
  • bacteriostatic
  • erythromycin (gentital infection)
  • azithromycin (long half life, ear and respiratory infections)
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15
Q

fluoroquinolone antimicrobials

A
  • gram negative
  • bactericidal
  • well absorbed
  • broad
  • used to treat urinary tract disease, respiratory, bone and soft tissue infection
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16
Q

upper respiratory infections preferred…

A

amoxicillin

17
Q

community acquired pneumonia preferred…

A
  • macrolides
  • azithromycin
  • clarithromycin
  • second gen cephalosporins
18
Q

chemotherapy

A

uses drugs to kill/stop cancer growth

19
Q

drug resistance

A

ability of bacteria to resist the effects of an antibiotic

20
Q

t/f penicillin is divided into 3 generations?

A

f!

2!

21
Q

1st gen penicillin

A

penicillin G & V

narrow spectrum

effective against gram positive bacteria

22
Q

2nd gen penicillin

A

ampicillin and amoxicillin

broad spectrum

effective against same bacteria as 1st gen + some gram negatives like Ecoli

23
Q

penicillin adverse effects

A

nausea/diarrhea/convulsions

24
Q

cephalosporins 1st gen

A

used to treat both gram positive + negative

25
Q

cephalosporins 3rd gen

A

broader
longer DOA
gram negative

26
Q

what cephalosporins can cross blood brain barrier

A

gen 3