Lesson 5

Question 1

A neurophil chemotactic agent -

Inhibits platelet aggregation and promotes vasodilation -

Answer 1

LTB

PCI 2

Question 2

Platelet gathering inhibitor, arrive “B4” Others

Answer 2

Neutrophils

Question 3

INFLAMMATION
Prostanoids Functions

Answer 3

MAINTAIN RENAL BLOOD FLOW AND GFR

INCREASE BODY TEMPERATURE

SENSITIZATION TO PAIN

GASTRIC PROTECTION

Question 4

Expressed consititutively (house keeping enzyme)

Responsible for the physiologic function of prostanoids

Answer 4

COX-1

Question 5

Readily Inducible

Major source of prostanoids in inflammation and cancer

Answer 5

COX-2

Question 6

Irreversible non selective cox inhibitors

Answer 6

Aspirin and Salicylates

Question 7

Reversible non selective cox inhibitors

Answer 7

Diclofenac

Ibuprofen

Indomethacin

Ketoprofen

Naproxen

Question 8

COX-2 SELECTIVE INHIBITOR

Answer 8

Celecoxib

Etoricoxib

Parecoxib

Question 9

ADVERSE EFFECTS FOR NSAIDS

CARIOVASCULAR -

GASTROINTESTINAL -

PULMONARY -

CNS -

HEMATOLOGIC -

HEPATIC -

Answer 9

MYOCARDIAL INFARCTION - BLACKBOX WARNING FOR CELECOXIB

ULCERS, ABDOMINAL PAIN, NVP / NSAIDS - COMMON CAUSE OF PEPTIC ULCER DISEASE

ASTHMA - LIKE ASPIRIN-INDUCED ASTHMA, NSAIDS EXACERBATION RESPIRATION DISEASE

HEADACHE, DIZZINESS AND TINNITUS

THROMBOCYTOPENIA, NEUROTROPENIA, APLASTIC ANEMIA

ABDOMINAL LIVER FUNCTION TEST

Question 10

ADVERSE EFFECTS FOR NSAIDS

CARIOVASCULAR -

GASTROINTESTINAL -

PULMONARY -

CNS -

HEMATOLOGIC -

HEPATIC -

Answer 10

MYOCARDIAL INFARCTION - BLACKBOX WARNING FOR CELECOXIB

ULCERS, ABDOMINAL PAIN, NVP / NSAIDS - COMMON CAUSE OF PEPTIC ULCER DISEASE

ASTHMA - LIKE ASPIRIN-INDUCED ASTHMA, NSAIDS EXACERBATION RESPIRATION DISEASE

HEADACHE, DIZZINESS AND TINNITUS

THROMBOCYTOPENIA, NEUROTROPENIA, APLASTIC ANEMIA

ABDOMINAL LIVER FUNCTION TEST

Question 11

NSAID THAT IRREVERSIBLY INHIBITS BOTH COX 1 AND COX 2. SYNTHESIS OF THROMBOXANE AND PROSTAGLANDIN

INCREASES BLEEDING TIME

Answer 11

ASPIRIN

LOW DOSES = DECREASED PLATELET AGGREGATION (300MG / DAY)

INTERMEDIATE DOSE = ANALGESIC AND ANTIPYRETIC (300-2400MG A DAY)

HIGH DOSE = ANTI INFLAMMATORY (2400-4000MG A DAY )

Question 12

ASPIRIN ADVERSE EFFECTS

Answer 12

REYE SYNDROME

GASTRIC ULCERATION

TINNITUS

CHRONIC USE: ACUTE KIDNEY INJURY

Question 13

REVERSIBLY AND SELECTIVELY INHIBITS COX 2, SPARES COX 1

Answer 13

Celecoxib

Question 14

REVERSIBLY INHIBIT BOTH COX 1 AND COX 2 BLOCKING PEPTIDOGLYCAN SYNTHESIS

Answer 14

NSAIDS

Question 15

INHIBIT THE SYNTHESIS OF VIRTUALLY ALL CYTOKINES

INACTIVATES NF -kB THE TRANSCRIPTION FACTOR THAT INDUCES PRODUCTION OF TNF-a

Answer 15

GLUCOCORTICOIDS / CORTICOSTEROIDS

Question 16

BINDS TO TUBULIN PREVENTING ITS POLYMERIZATION INTO MICROTUBULES INHIBITION OF LEUKOCYTE MIGRATION AND PHAGOCYTOSIS

USED FOR TERMINATION OF ACUTE ATTACKS FOR PROPHYLAXIS

DOES NOT ALTER METABOLISM OR EXCRETION

Answer 16

COLCHICINE

Question 17

TREATMENT FOR CHRONIC GOUT AND TENDS TO PROLONG THE INTERICAL PERIOD

USED TOGETHER WITH COLCHICINE/ NSAIDS DURING INITIATION

Answer 17

XANTHINE OXIDASE INHIBITORS

ALLOPURINOL FEBUXOSAT

Question 18

CONVERTS URIC ACID TO A MORE SOLUBLE ALLANTOIN

MAINTAIN LOW URATE LEVELS FOR UP TO 21 DAYS AFTER

Answer 18

PEGLOTICASE