Lesions of the cervix

Question 1

Pathogenesis of SCC in high risk hpv

Answer 1

HPV infects cells and its DNA is integrated into the host genome
Early viral genes E6 and E7 disrupt the cell cycle regulatory proteins
E6 disrupts p53
E7 disrupts the retinoblastoma gene (RB)
The cell goes into an uncontrolled proliferation
Acquires further DNA damage