Leptospirosis (Week 6) Flashcards

1
Q

Leptospires has a predilection for:

A

Kidneys
Liver
Spleen
CNS
Eyes
Genital Tract

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2
Q

a raised level in the blood of urea and other nitrogenous waste compounds that are normally eliminated by the kidneys

A

uremia

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3
Q

GI signs are common with ______________, and generally, with all AKI

A

leptospirosis

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4
Q

What can dogs with lepto have?

A
  • Painful muscles and joints and ache all over
  • Uveitis
  • Meningitis is not common manifestation of lepto, but in cases of meningitis and fever without an obvious cause, consider lepto
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5
Q

What is you see AKI with liver damage and thrombocytopenia?

A

Suspicions for lepto is really high

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6
Q

(T/F) All dogs with lepto have liver damage

A

False

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7
Q

What is a classic test for lepto?

A

MAT - measures the amount of antibody present

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7
Q

What is a classic test for lepto?

A

MAT - measures the amount of antibody present

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8
Q

What are you doing until you have a second
titer back to confirm a
negative?

A

Treating all dogs with AKI as possible lepto cases

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9
Q

A highly _________ test is a good screening test, and a negative means the disease is unlikely, but tend to have a lot of False Positives

A

sensitive

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10
Q

A highly __________ test
is used to confirm disease. It should have few false positive results, but could miss some cases

A

specific

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11
Q

With this test, a Positive Test means the dog HAS lepto; a Negative test means you should test again in 7-10 days

A

Zoetis Witness Test

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12
Q

With this test, a positive test doesn’t tell you much, but a Negative test increases my suspicion that the dog does NOT have lepto

A

Idexx Snap Test

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13
Q

MAT: What is considered a presumptive diagnosis?

A

single titer of 1:800 or higher (with clinical signs and absence of recent vaccination)

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14
Q

What are are excellent first choice drugs because they are safe with kidney disease and kill leptospires in the blood?

A

Penicillin and its derivatives like Ampicillin

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15
Q

What is the unfortunate thing about ampicillin?

A
  • they don’t kill leptospires in the kidney
    - don’t kill leptospires in the urine
16
Q

What drug do you use to kill leptospires in the kidney?

A

Doxycycline or Erythromycin

17
Q

Can be used as a first line drug, because it gets the leptospires in the blood and in the kidneys

A

Doxycycline

18
Q

Tetracyclines and their derivatives are effective against the__________ state

A

carrier

19
Q

Doxycycline is also effective for the ____________phase

A

leptospiremic

20
Q

Erythromycin is effective for the ___________ state

A

carrier

21
Q

Approximately ___________ of dogs with leptospirosis survive

A

80-90%

22
Q

During what period of time will MAT titers be hard to interpret?

A

within the 3 month
window
(after vaccination)

23
Q

What species is resistant to lepto?

A

Cats

24
Q

effectively kill leptospires in the kidney

A

Tetracyclines (and erythromycin)