Lens Flashcards
Power of lens
16 to 17 dioptres
Refractive index of lens
1.39
Refractive index of nucleus of lens
1.4 to 1.41
Diameter of lens
9 to 10 mm
Different layers of the lens according to age
From inner (oldest) Embryonic Foetal Infantile Adult Cortex
Till what time period lens fibres are formed
Throughout life
Youngest fibres of the lens
Cortex
Thinnest part of lens
Capsule and posterior pole
4u
Primary metabolism of lens
Aerobic or anaerobic?
Anaerobic – 80% or more
Where does the lens derives its nutrition from
Aqueous humour
Which Germ layer is lens derived from
Surface ectoderm
Definition of cataract
Any opacity of lens which hinders the optical homogenicity
Genes involved in congenital cataract
- CRY-Crystalline
- cx-connexins
- MIP – Mayor Intrinsyc protein
TORCHS full form
Toxoplasma, others,rubella, CMV, herpes, syphilis
Most common cause in congenital cataract is
blue dot cataract
Most common cause for diminishing vision in congenital cataract is
Lamellar/zonular cataract
Cataracta pulverulenta
Powdery appearance of opacity
Which track track has onion peel appearance in congenital cataract
Posterior polar cataract
Which vitamin deficiency causes lamellar cataract
Vitamin D deficiency
Triad of congenital rubella syndrome
Cataract-Nuclear pearly cataract (most common)
Heart defects
Deafness
Mnemonic
CHD – congenital heart defect
Most common ocular feature of congenital rubella syndrome
Salt and pepper fundus
What is the pathology of salt-and-pepper fundus
Diffuse Choreoretinitis
Salt and pepper fundus differential diagnosis
- rubella
- syphilis
- retinitis pigmentosa
- myotonic dystrophy-Christmas tree cataract
5 Ps of myotonic dystrophy
- ptosis
- Presenile cataract
- IOP is low
- pigmentary retinopathy
- pupil miotic reacting slowly to light
Per-senile cataract causes
Myotonic dystrophy
Atopic dermatitis (Shield cataract)
Diabetes
Amaurosis
Total loss of vision
Amblyopia
Partial loss of vision
Amaurosis fugax
Transient loss of vision in curtain like manner
Time Of operating in congenital cataract
One month to 5/6 months
Treatment of choice in congenital cataract
Lens aspirations/lensectomy
Primary posterior capsulotomy
Anterior with direct to me
IOL implantation
Foveal reflex formed at what age
5–6 months
Why do we prescribe near glasses after a cataract surgery
Because accommodation is a lost after cataract surgery
Three ways of classification of acquired cataract
Aetiological
According to maturity
Anatomically
Which lenticular opacity causes maximum diminution of vision
Posterior Subcapsular
Why does posterior sub capsular cause maximum diminution of vision
As it is near the nodal point of eye
Two types of senile cataract
Cortical cataract and nuclear cataract
Stages of cortical cataract
Lamellar separation Incipient cataract/intumescent cataract Immaturecataract Mature cataract Hypermature cataract
Most common complication of cortical cataract
Phacolytic glaucoma
Aetiology of cortical cataract
Hydration
Aetiology of nuclear cataract
Nuclear sclerosis
.1 deposition of insoluble protein
2. deposition of pigments(Melanin and urochrome)
Clinical features of nuclear cataract
Immature cataract
Mature cataract
Hypermature nuclear sclerotic cataract
Most common complication of nuclear cataract
Subluxation of lens
Most common cause -trauma
Second sight of old age
Improvement in near glasses
Nuclear cataract feature
Why does second sight happen
Due to nuclear sclerosis there is increased refractive index of lens which increases the refractive power of the lens
How can a person out of 40 or above have a emmetropic eyes
The person has had hypermetropia before 40 or
If myopia after 40
Differential diagnosis for frequent change of glasses
Early cataract (intumescent) Late glaucoma (POAG) Diabetes
hyperglycaemia and hypoglycaemia have what shift
Hyperglycaemia has myopic shift (eg.-3 to -6)
Hypoglycaemia has hypermetropic shift (e.g.-3 to -1)
Pathology behind myopic and Hypermetropic shift
In hyperglycaemia the lens swells up
Therefore the lens has more power
Therefore it causes myopia
Differential diagnosis coloured halos
Cataract
Acute congestive glaucoma—> corneal edema
Mucopurulent conjunctivitis
Fincham test
Passing stenopic slit in front of eye
If halos break - cataract
If halos don’t break- acute congestive glaucoma
Metabolic cataract causes
Diabetes
Galactosemia
Chaliosis
Lowe’s syndrome/oculo cerebro-renal syndrome
Features of metabolic cataract in diabetes
Sorbitol pathway
NADPH dependent aldose reductase
Snowstorm/ snowflake cataract
Most common in type one diabetes
Reversible cataract
Galactosaemia metabolic cataract
By avoiding milk products
Kayser flesher ring (chaleosis)
Features in the lens in Lowe’s syndrome
- metabolic cataract
- microphakia less than 9 mm
- posterior Lenticonus
What type of lenticonus in Alports syndrome
ANTERIOR lenticonus
and posterior
(Can have both)
What is complicated cataract
Cataract occurring as a complication to anterior segment or posterior segment disease
Pathognomic feature of complicated cataract
Polychromatic lustre
Breadcrumb appearance
Complicated cataract
Most common type of complicated cataract
Posterior sub capsular
Drugs causing toxic cataract
- steroids
- phenothiazine
- long acting miotics
- Amiodarone
- gold
- busulfan
- chloroquine
Drugs causing anterior sub capsular cataract
Phenothiazine
Long acting miotics
Amiodarone
Gold
Drugs causing posterior sub capsular cataract
Steroids
Busulfan
Chloroquine
Most common complication of steroids in eye
Glaucoma
Most common complication after topical steroids
Glaucoma
Open angle
Most common complication of the systemic steroids
Cataract
Post subcapsular
Radiational Cataract is seen in what occupation
Glass worker(Infrared) Protected technicians, patients treated for malignant tumours, workers of atomic energy plants (Irradiation cataract) Senile cataract (UV radiation cataract)
Most common type of radiation cataract
Posterior sub capsular
Most common type of radiation cataract
Most common cause of complicated cataract
Cataract caused due to steroids-most common
Maximum diminution of vision in which cataract
Posterior sub capsular
Most radio sensitive part of the eye
Lens
Most radio resistant part of the eye
Sclera
Most radio sensitive part of the retina
Photo receptors (rods and cones)
Most radio resistant part of retina
Ganglion cell layer
Traumatic cataract features
Rossette shape cataract
Vossius ring
Berlin’s edema/commotio retinae
(If you don’t know what these are pls check notes)
What forcep is used for extraction of the capsule in intra capsular cataract extraction
Arugas forceps
Only indication of ICCE
Subluxation of lens
What is the contract indication of ICCE
It is contraindicated in children
This is because the Weigerts ligament attaches the capsule and the anterior hyaloid membrane which may pull the vitreous during ICCE which is a big risk of retinal detachment
Two parts of an IOL
Optics and haptics
What are IOLs made up of
PMMA
Polymethyl methacrylate
Foldable IOLs material
Acrylic (most common)
Silicon
Hydrogel
Incision size in phacoemulsification
2.75-3.2 mm
What dye is used to stain the capsule
Triptan blue dye
Wavelength of femtolaser
1054 nm
Pulse duration of femtolaser
10 to the power of -15 seconds
Different sites for IOL
- anterior chamber
- Iris claw lens
- scleral fixated
What is biometry
Method of calculating the power of IOL
What is used to measure the axial length
A scan
What does keratometry measure
Measuring curvature
SRK formula
P = A -2.5 -0.9 K
A is a constant
If Cornea diameter is more than 26 mm which formula do you use to calculate the power
SRK/t
Other formula is used to calculate the power of IOL
Holladay Formula
Morphological types of after cataract
Diffuse
Elschnig’s pearls
Soemmering’s rings
Treatment of each type of after cataract
Dense membranous- surgical membranectomy
Elshnig’s-YAG laser + posterior capsulotomy
Soemmerings ring-no treatment
Ocular features of marfans syndrome
- axial myopia
- Megalocornea >13mm (Most prominent)
- supra temporal ectopia lentis
- lattice degeneration
- retinal detachment
Shield cataract is seen in which condition and what site opacity is present
Atopic dermatitis
ASC opacity
Ectopia lentis in Marfans syndrome
Superior temporal
Ectopia lentis in homocystinuria
Inferonasal
Ectopic lentis in weil marchesani
Inferonasal
Micro spherophakia
features of Ehler Danlos
Blue sclera
Downward and forward ectopic lentis
Subluxation of lens main features
Simple ectopia lentis
Ectopia lentis et pupillae
Ectopia lentis associated with syndrome
(Also know what they mean -.-)
Endophthalmitis early onset cause
Staphylococcus epidermidis
Endophthalmitis late onset causes
Propionibacterium acne
Fungal- MC candida
MCC subluxation of lens
Trauma
Most dreaded complications of cataract surgery
Endophthalmitis
MC long term/late complications after cataract surgery
After cataract