LeDoux 1988

Question 1

Describe the method of LeDoux and colleagues 1988

Answer 1

Electrolytic lesions (which destroy neurons and fibers of passage) and ibotenic acid lesions (which spare fibers of passage) of CeA

Question 2

LeDoux et al 1988 Results

Answer 2

Lesion to caudal CG (by either method)- reduced conditioned freezing, no impact on arterial pressure
Lesion to lateral hypothalamus- impaired conditioning of changes in mean arterial pressure

CeA projection to Caudal Central Gray- conditioned emotional behavior (freezing)
CeA projection to lateral hypothalamus- conditioned autonomic response (mean arterial pressure)