Lectures 3-7 Descriptive Epidemiology Flashcards

1
Q

What are the two “descriptions” of measurement used when determining the distribution of a disease?

Which of the 3 W’s are these measurements referring to?

A
  1. Frequencies of the Disease - Relative to the size of a population. For comparative purposes, the population size has to be similar
  2. Patterns of disease - Evaluating disease with respect to persons, place, and times

Determining Who/Where/When are the components of descriptive epidemiology.

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2
Q

What is the basic purpose of Descriptive Epidemiology?

A

Descriptive Epidemiology can be used to determine if a location is experiencing disease occurrence More Frequently Than Usual, or more than other locations.

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3
Q

What are Surveillance Systems? Name the 3 main types of surveillance systems.

A
  • The study of determining whether or not there is disease in a population.

Three types include Passive Surveillance Systems, Active Surveillance Systems, and Syndromic Surveillance systems.

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4
Q

Briefly describe passive surveillance systems

A

Relies on standardized reports of disease to come in from healthcare systems such as clinics and hospitals. These systems are required by law to follow regulations on reporting these conditions.
- The Public health system passively waits for reports to come in, in order totrack disease frequency/occurrence over time and within populations

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5
Q

Briefly describe Active Surveillance Systems

A

Public health officials actively go into communities to search out new disease cases/conditions

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6
Q

Describe Syndromic Surveillance Systems

A

This system looks for pre-defined signs or symptoms of patients related to trackable but rare conditions or diseases. Asking physicians/hospitals to keep an eye out for red-flag syndromic symptoms, such as fever/body-aches during flu season would count as this.
- Biosurveillance can consist of humans, animals, plants, or environmental factors

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7
Q

List the 4 stages of clinical disease, including any significant events that occur during them

A
  1. Stage of Susceptibility - Patient is at risk, but uninfected. Stage ends at first exposure.
  2. Stage of Subclinical Disease - From the time of exposure to first onset of symptoms. Pathological changes can occur before symptoms.
  3. Stage of Clinical Disease - Technically the duration of the disease after first symptoms. Diagnosis usually occurs shortly into this stage.
  4. Stage of Recovery, Disability, or Death
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8
Q

What is the induction period? Latency Period? Incubation Period?

A

Induction - Time Between Disease Exposure and Disease Onset
Latency - Time between Onset of Disease (?) and First Symptoms or Signs

Incubation - Similar to Induction, Incubation is meant more for infectious diseases, while induction is more broad-based and includes chronic diseases

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9
Q

What is the most important aspect of the disease that must be determined before descriptive epidemiology procedures can begin?

Describe CSTE and NNDSS

A

CASE definitions - A set of uniform criteria for respective diseases for public health surveillance. Enables consistency across multiple states and divisions of epidemiology.

The CDC-run Council for State or Territorial Epidemiology (CSTE) recommends diseases be reported to National Notifiable Diseases Surveillance System (NNDSS), whereupon the CSTE updates their list of case definitions for infections and non-infectious diseases uniformly every year.

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10
Q

Why are case Definitions Important?

What’s the difference between probable case definitions and confirmed?

A

It is important for epidemiologists to carefully and consistently define and execute how diseases will be diagnosed, and then to properly and Accurately count the frequency.

It’s not confirmed until laboratory/diagnostic evaluations have definitive results. Probable case definitions are used more commonly for more extreme diseases.

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11
Q

What is the difference between an epidemic, and an outbreak. Describe both.

A

Epidemic - Occurrence of a disease is significantly higher than normal. The community can be as small of a population as a zip code, or as large as a country, but the community and period must be clearly defined. The goal is to capture disease as early as possible.

Outbreak - Similar to an epidemic, but a more localized increase in disease occurrence, such as a school; Sometimes referred to as a Cluster

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12
Q

What are general rules of thumb with seasonal epidemics

A

Seasonal Outbreaks can’t really be considered epidemics unless they’re compared with Last Year’s Averages. It can’t “just” be compared with last year’s numbers because it’s always possible that last year involved an outlier or abnormal frequency of some kind.

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13
Q

Name the 3 escalating categorizations for Epidemic Severity and describe their characteristics

A
  1. Endemic - Standard category for the constant presence of a disease in excess of a normal level in a localized region.
  2. Emergency of International Concern - Epidemic that alerts the entire world to the need for higher vigilance of a disease. Included Polio scare of 2014
  3. Pandemic - Epidemic that is spread world-wide. Included the H1N1 Pandemic of 2009.
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14
Q

What is the epidemic curve?

A

A visual time-based depiction of the spread of a disease during an outbreak or epidemic. Must visually depict the Shape of the disease spread. Includes a Common/Point Source (Beginning) that is either intermittent thereafter, or continuous. (Suggests the disease is mostly spread from a single person, or single source)
A propagated source (more of a steady bell curve increase) suggests that it’s contagiously spread person-to-person

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15
Q

What are some “points” in the epidemic curve that one should look for to help determine magnitude and timing of disease?

A

Sentinel (Initial) index case
Peaks
Outliers
Start/Stop Duration (Time)

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16
Q

What sorts of hypotheses can be determined from analyzing the epidemic curve?

A

Routes of Transmission
Probable Exposure Period
Incubation Period - May help to identify or eliminate causes

17
Q

What is the difference between a point source and a sentinel index case

A

Point sources do not necessarily come from a person; whereas sentinal index cases have that initial “sick person” that is first seen before future outbreaks occur.

Note: Sometimes, propagated transmission often appears intermittent do to each “batch” of new cases exposing disease to others, followed by an induction period before the next phase of the outbreak occurs.

18
Q

What is the difference between absolute and relative differences? Name the 3 Relative measures of disease frequency.

A

Absolute looks at Exact counts of disease #s in the entire population (uncertain about this one), whereas relative differences compares the numbers of cases between separate populations.

  1. Ratio - Division of Two Unrelated Numbers
  2. Proportion - Division of Two Related Numbers
  3. Rate - A proportion with time incorporated into the denominator
19
Q

What are the 3 key factors that need to be known in order to compare the relative frequencies between two populations?

A
  1. Number of people affected or impacted (Frequency/Count)
  2. Size of the source Population from which the disease arose, or at least the size of the people at risk.
  3. Length of time the population is followed (To synchonize, the person-years must be equal or (Each person counts for as many people as the years they were followed)
    (Realistically, the population size and time followed MUST be equal to appropriately compare diseases.)
20
Q

Define Incidence Rate and Prevalence Rate

A

Incidence: (# of New Cases of A Disease Within that Time)/(Total Number of people At Risk within that population)

Prevalence: (Total # of people who currently have the disease)/(Total Number of People At Risk within that population)

Sometimes Incidence is known as Risk, Attack Rate, or Cumulative Incidence)

21
Q

What are some drawbacks to using the Incidence Rate

A
  • It’s mandates that the time frame for the numerator and denominator must the same (not much of a drawback, but important)
  • It’s not very efficient for dynamic, constantly changing populations. (In these instances, one should use the population at the start of the year, average population, or mid-year population)
22
Q

What is incidence density and how is it more useful?

A

In dynamic shifting populations, incidence density is (# of new cases of a disease) / (total person-time of At Risk population)

  • Makes it easier to track different people for different durations of time. Generally Repeat Cases of diseases are only counted once
23
Q

Define Prevalence.

What are the 2 main types of prevalence?

A

Prevalence (Total # of infected/Total # at risk)

  1. Point Prevalence - Prevalence at a Certain time, such as 12/31/2013
  2. Period Prevalence - Prevalence over a longer period of time.
24
Q

In 1989, 733,151 new cases of gonorrhea werereported among the US civilian population. The1989 mid‐year US civilian population wasestimated to be 246,552,000. Whatisthe 1989 USincidence rate of gonorrhea (per100,000 population)?

A

Incidence = (733,151 New Cases / 246,552,000 Total) * 100,000 (standardized) = 297.3

25
Q

Seven cases of hepatitis A occurred among 70children attending a child care center. Eachinfected child came from a different family. Thetotal number of persons residing in the homes ofthe 7 affected families was 32. One incubationperiod later, 5 family members of the 7 infectedchildren also developed hepatitis A. What was the secondary attack rate?

A

0.20 or 20%.

32-7 = 25

5/25 = 20%. Don’t count those who already have it.

See Slides 44-49 for more practice problems

26
Q

Define the following terms:

  1. Crude Morbidity Rate
  2. Crude Mortality Rate
  3. Cause Specific Morbidity Rate
  4. Cause Specific Mortality Rate
A
  1. (# of people with disease)/(Total Population) *Count people with multiple diseases only once
  2. (# of people died) / (Total Population)
  3. (# of people with specific disease)/ (Total Population)
  4. (# of cause specific deaths)/(Total Population)
27
Q

Define the Following:

  1. Case-Fatality Rate
  2. Cause-Specific Survival Rate
  3. Proportional Mortality Rate (PMR)
A
  1. (# of cause-specific deaths / # of disease cases)
  2. (# of cause-specific cases alive/ # of cases of disease)
  3. (# of cause-specific deaths/ total # of deaths in the population)
28
Q

Define the Following:

  1. Live Birth Rate
  2. Fertility Rate
  3. Neonatal Mortality Rate
  4. Post-natal Mortality Rate
A
  1. # of Live Births/1,000 Population *Almost always standardized to 1000
  2. # of Live Births/1,000 Women Aged 15-44
  3. # of Deaths of babies = 28 Days, But
29
Q

Define the Following:

  1. Infant Mortality Rate

2. Maternal Mortality Ratio

A
  1. (# of deaths of people under 1 years of age)/1,000 Live Births
  2. (# of Female Deaths Related to Pregnancy)/ 100,000 Live Births *Watch that new number
30
Q

Define The Following:

  1. Infectivity
  2. Pathogenicity
  3. Virulence
A
  1. The Ability to invade a patient
    # of Infected / # of Susceptible
  2. The Ability to Cause Clinical Disease
    # With Clinical Disease/# of People Infected
  3. Ability to cause death (Same as Case Fatality Rate)
    # of Deaths/# with infectious disease