Lecturer: Hemostasis

Question 1

KEY TERM

Three phases of hemostasis:

Answer 1

primary: formation of platelet plug
secondary: coagulation

tertiary: fibrinolysis

Question 2

What is von Willebrand factor? (2)

Answer 2

protects factor 8 from rapid inactivation

binds platelets

Question 3

KEY TERM

What is the most common congenital bleeding disorder?

Answer 3

Von Willebrand’s disease

Question 4

Most comon agonists for platelet activation: (3)

Answer 4

collagen

thrombin

epinephrine

Question 5

What are the primary adhesive molecules? (2)

Answer 5

fibrinogen

vWF

Question 6

What is the fibrin stabilizing factor?

Answer 6

8

Question 7

What are vitamin K dependent factors? (4)

Answer 7

2

7

9

10

Question 8

Deficiency of factor 8 results in:

Answer 8

hemophilia A

Question 9

Deficiency of factor 9 results in:

Answer 9

hemophilia B

Question 10

Neonates have a well balanced, efficient hemostatic system. True or false?

Answer 10

true

Question 11

Fetal form of fibrinogen exists until ___ year of age.

Answer 11

1

Question 12

Fibrin clot of neonates are less dense. True or false?

Answer 12

true

Question 13

Off label use of factor 7:

Answer 13

post-cardiopulmonary bypass

Question 14

What model provides an in vivo model of the coagulation process?

Answer 14

Cell-based model