Lecture VIII Flashcards
Morphine
Mu-receptor Uses: Severe Pain Side Effects: Constipation, Addiction, Tolerance Notes: Antidote: Naloxone
Codeine
Mu-receptor Uses: Cough, Diarrhea, IBS, Narcolepsy Side Effects: Euphoria, Itching, Depression, Constipation Notes: Metabolite is morphine
Mu2 Receptor
Respiratory depression, miosis, euphoria, decrease GI motility, physical dependance.
Kappa Receptor
Spinal analgesia sedation, miosis, dysphoria, decreased ADH release
Delta Receptor
Analgesia, anti-depressant effects, physical dependance
Naloxone
Mu, Delta and Kappa receptor antagonist Use: Opiod antidote Side Effects: Change in mood, Trembling, Change in heart rhythm
Meperidine
K-Receptor Uses: Severe Pain Side Effects: Seizure, Dysophoria, Tremor, Respiratory Depression Notes: Binds to K+ Channels, Muscarinic receptor. DONT USE NALOXONE
Mu1 Recept
Supraspinal analgesia, physical dependance
Pentazocine
Mu-receptor antagonist Delta & Kappa receptor agonist *** Due to enantiomers*** Uses: Dental Extraction Side Effects: Hallucinations, Psychotomimetic effects, CV effects Notes: Antagonizes the analgesic effects of morphine and meperdine
Hydrocodone
Mu receptor & Delta receptor Uses: Moderate Pain/Anti-coughing Side Effects: Constipation, Respiratory Depression, Nausea Notes: Recreational Drug
Methadone
Mu & Delta receptor Agonist Use: Treatment of dependance on opiod drugs Firm occupancy of opioid receptors by methadone causes decrease in desire for other opioid intake, because it is producing an effect that stop withdrawal manifestations. With time addicts improve and decrease craving Side Effect: Dependance
Opiates CNS effects
M-iosis O- out of it (sedation) R- respiratory Depress P-ainless H- Hypothermia I- Infrequency GI movement N-o coughing E-uphoria
