Lecture I

Question 1

Metyrosine

Answer 1

Competitive inhibition of Tyrosine Hydroxylase

Question 2

Reserpine

Answer 2

Inhibits VMAT vesicular uptake of monoamines

Question 3

Bretylium

Answer 3

Inhibits AP generation and calcium dependent synaptic vesicle fusion- important for Neuropeptide transmitters which need longer AP in order to stimulate release

Question 4

Cocaine

Answer 4

Blocks monoamine reuptake

Question 5

Amphetamine/Ephedrine

Answer 5

Reverses monoamine reuptake transporters

Question 6

Nalaxone, Naltrexone

Answer 6

Non-peptide blockers of opioid receptors in CNS

Question 7

SSRIs

Answer 7

Seratonin specific reuptake inhibitors

Question 8

ACE inhibitors i.e. lisinopril

Answer 8

Inhibits peptide cleavage of Angiotensin I to Angiotensin II

Question 9

Phenylephrine

Answer 9

Agonist of Adrenergic receptors (specifically Alpha 1)

Question 10

MAO Inhibitors

Answer 10

Inhibit MAO, preventing the degradation of neutrotransmitters in the cytoplasm. Causing an increase in neutrotransmitter in the cytoplasm thereby causing it to spill out

Question 11

L-DOPA

Answer 11

precursor to dopamine that stimulates DA production

Question 12

Carbidopa

Answer 12

Prevents the metabolism of L-DOPA into DA before it crosses the BBB. Carbidopa does not cross the BBB so once L-DOPA crosses it, it will be able to be converted to DA.

Question 13

Tyramine

Answer 13

Tyramine competes with NE for transport into synaptic vesicles. Causes an increase in NE in the cytosol.