Lecture: Neurotransmitters Flashcards
amino acid neurotransmitter(s)
Glutamate
Aspartate
Glycine
GABA
What are the two categories of monoamines?
Catecholamines
Indolamines
Monoamine catecholamine neurotransmitter(s)
Dopamine
Epinephrine
Norepinephrine
Monoamine Indolamine neurotransmitter(s)
Serotonin
Soluble gas neurotransmitters
Nitric oxide
Carbon monoxide
Acetylcholine neurotransmitter(s)
Acetylcholine
Which neurotransmitter is its own class?
Acetylcholine
Neuropeptide neurotransmitter(s)
Endorphins
Most common excitatory neurotransmitter in the bran
Glutamate
Predominant ionotropic Glutamate receptor
NMDA
What neurotransmitter is termed the “on switch” for the brain?
Glutamate
Glutamate ionotropic receptor(s)
AMPA
NMDA
Kainate
Glutamate metabotropic receptor(s)
mGluRs
Neural injury that causes excess release of glutamate, killing neurons
Excitotoxicity
What results in excitotoxicity
Stroke
Head Trauma
Most common inhibitory neurotransmitter in the brain
GABA
Ionotropic GABA receptor(s)
GABA subscript A
GABA agonists are potent ______
Tranquilizers
GABA agonists:
Valium
Barbiturates
Ethanol
Neurosteroids
Benzodiazepines
What might benzodiazepines be used for?
Stop seizures
Antidepressants
What might barbiturate be used for?
Sleeping pills
Anesthesia
What is the neurotransmitter in alcohol?
Ethanol
Most common inhibitory neurotransmitter in the spinal cord
Glycine
What is the neurotransmitter for adrenaline?
Epinephrine
What does dopamine facilitate?
Addiction
Learning
Schizophrenia
Motor Control
Dopamine pathway(s)
Mesolimbocortical
Mesotriatal
Where does the mesotriatal pathway go for dopamine?
Substantia nigra to striatum
(Caudate and putamen)
Where does the mesolibocorotical pathway go for dopamine?
Ventral tegmental area to nucleus accumbens, cortex, and hippocampus
What is Norepinephrine vital for?
Mood
Arousal
Sexual Behavior
Where does the norepinephrine pathway travel?
Locus Coreleus to hippocampus, basal ganglia, and cortex
Lateral Tegmental area
What is serotonin vital for?
Sleep
Sexual Behavior
Anxiety
What neurotransmitter is responsible for anxiety and panic attacks?
Serotonin
What structures are vital to the serotonin pathway?
Hippocampus (under the surface) and Raphe Nuclei
What is the serotonin pathway?
Mesencephalic serotonergic cells project to thalamus, hypothalamus, basal ganglia, and cortex
What state of matter are the nitric oxide and carbon monoxide neurotransmitters?
Gasses
Nitric oxide is produced in _____ of the _____ cell and diffuses _____
Dendrites
Postsynaptic
Instantly
Gas neurotransmitters are diffused to ____ cells
Nearby
Gas neurotransmitters _____ neighboring neurons
Synchronize
Can gasses be stores in vesicles?
No
Acetylcholine receptor(s)
Nicotinic
Muscarinic
Agonists for acetylcholine
Nicotine
Muscarine
What is Curare good for?
Helps with suffocation from seizures
Relaxes muscles and paralyzes patients
Most nicotinic ACh receptors are:
Ionotropic
Excitatory
Peripheral
Most muscarinic ACh receptors are:
Metabotropic
Excitatory or inhibitory
CNS
_____ use nicotinic ACh receptors
muslces
Is glutamate excitatory or inhibitory?
Excitatory
Is asparate excitatory or inhibitory
Excitatory
Is glycine excitatory or inhibitory?
Inhibitory
Is GABA excitatory or inhibitory
Inhibitory
Is dopamine excitatory or inhibitory?
Neither
Is epinephrine excitatory or inhibitory?
Excitatory
Is norepinephrine excitatory or inhibitory?
Excitatory
Is serotonin excitatory or inhibitory?
Inhibitory
Is nitric oxide excitatory or inhibitory?
Both
Is carbon monoxide excitatory or inhibitory?
inhibitory
Is acetylcholine excitatory or inhibitory?
Excitatory
Are endorphins excitatory or inhibitory?
Inhibitory