Exam 1 Case Studies

Question 1

What did trey have?

Answer 1

Edema

Question 2

What is Edema?

Answer 2

Excessive fluid in the brain

Question 3

What happened to trey?

Answer 3

He ran into a car and died 5 hours later

Question 4

What did the 14 y/o Vietnamese girl have?

Answer 4

Right-side stroke

Question 5

What were treys symptoms?

Answer 5

Alert at first, then became lethargic

Question 6

What were 14yo Vietnamese girl’s symptoms?

Answer 6

First couldn’t move right arm or see to her left
A month later unable to move left arm and hearing was worse

Question 7

What was 14yo Vietnamese girls developmental symptoms?

Answer 7

Short, thin, and hard of hearinh

Question 8

What did 36yo engineer at TI have?

Answer 8

Astrocytoma

Question 9

What were 36yo engineer’s symptoms?

Answer 9

Incoordination of left arm and tendency to fall to left, along with headaches

Question 10

What is the key word for astrocytoma?

Answer 10

headaches

Question 11

What did Rolf have?

Answer 11

Alexander disease

Question 12

What is Alexander disease

Answer 12

Astrocytes fill up with GFAP, then fail

Question 13

Who was the 15 month-old boy admitted for continual screaming, vomiting, and englarged head?

Answer 13

Rolf

Question 14

What happened to Rolf?

Answer 14

He deteriorated and died 3 weeks later

Question 15

Where is GFAP found?

Answer 15

Astrocytes

Question 16

What did Alex have?

Answer 16

Lowe syndrome

Question 17

What does Lowe syndrome damage?

Answer 17

Golgi body

Question 18

What chromosome is Lowe syndrome linked to?

Answer 18

X

Question 19

What body structures does Lowe syndrome affect?

Answer 19

Eyes, brain, and kidneys

Question 20

What were Alex’s symptoms

Answer 20

Hardly ever cried and found cataracts as a baby
became severely retarded in 4 months

Question 21

What did Sheila have?

Answer 21

Tetanus

Question 22

What does tetanus do on the neurotransmitter level?

Answer 22

Glycine inhibits ecvess body movements

Question 23

What is the poison in tetanus

Answer 23

Tetanospasmin

Question 24

What does tetanospasmin do on the neurotransmitter level?

Answer 24

Inhibits glycine

Question 25

What is the effect of tetanospasmin inhibiting glycine?

Answer 25

muscle stiffness/ contractions

Question 26

What body parts does tetanus especially effect?

Answer 26

Jaw and neck

Question 27

What were Sheila's symptoms?

Answer 27

Face began to ache and difficulty opening mouth

Question 28

What happened to Sheila after going to doctor?

Answer 28

jaw stiffness and severe back and limb spasms

Question 29

How old was the case that ate Fugu?

Answer 29

32 man

Question 30

What were the symptoms in the Fugu case?

Answer 30

tingling in the tongue and right side of mouth Light feeling Anxiety Thoughts of dying

Question 31

What is the animal in Fugu?

Answer 31

Pufferfish

Question 32

What is the chemical in pufferfish?

Answer 32

Tetrodotoxin

Question 33

What does tetrodotoxin do?

Answer 33

Block Na+ gated channels

Question 34

What is periodic paralysis

Answer 34

LoF mutation of Na+ channels in muscles

Question 35

Does periodic paralysis cause less or more depolarization?

Answer 35

Less

Question 36

What happened to Don?

Answer 36

Dopamine agonist caused impulse control issues

Question 37

Who was the retired accountant?

Answer 37

Don

Question 38

What were Don's symptoms?

Answer 38

Tremor and slowing of movements

Question 39

What was Don's initial diagnosis?

Answer 39

Parkinson

Question 40

What was don prescribed for parkinson's

Answer 40

Levodopa

Question 41

Why was Don switched from levodopa to ropinirole

Answer 41

Motor systems started to fluctuate

Question 42

What happened after Don switched to ropinirole

Answer 42

Gamgling

Question 43

What was don's rapinirole replaced with?

Answer 43

a MAOI

Question 44

What happened when Don got on MAOIs?

Answer 44

gambling disappeared

Question 45

Symptoms of opiate overdose?

Answer 45

Dilated pupils (2mm) and barely react to light

Question 46

Are drug overdose death rates increasing or decreasing?

Answer 46

Increasing

Question 47

What did B-19 initially suffer from?

Answer 47

Depression and obsession-compulsion disorder

Question 48

How was B-19 initially reated?

Answer 48

Electrodes implanted at nine sites and left for 3 months

Question 49

Which electrode produced pleasure in B-19?

Answer 49

near the MFB

Question 50

Was the treatment for B-19 addictive?

Answer 50

Yes

Question 51

What did B-19 stimulate himself to the point of?

Answer 51

Overwhelming euphoria and elation

Question 52

How old was B-19?

Answer 52

24yo man

Question 53

What was being stimulated by B-19s electrode

Answer 53

VTA via median forebrain bundle

Question 54

Did B-19 protest turning the electrode off?

Answer 54

Yes

Question 55

What did the B-19 experiment simulate?

Answer 55

Addiction