Lecture Exam 2 Flashcards
Response of VE to exercise
Increase linearly and then greater linearly at AnT
Lower VE in trained individuals
Trained individuals can go to greater work rate and higher VE
Reponse of VCO2 to exercise
Increase linearly and then greater linearly at AnT
Lower VCO2 in trained individuals
Trained VCO2 can go to greater work rate and higher VCO2
Response of VO2 to exercise
Increases linearly until plateau or decrease
Trained individuals can go to higher VO2 and work rate
Causes for breakaway (AnT) in VE
- Increase (breakaway) in VCO2
2. Increase lactate (Breakaway), decrease pH due to an increase of H+
Cause for breakaway (AnT) in VCO2
Breakaway in lactate production
Training effects on:
VE
VCO2
VO2
Decrease
Decrease
Increase VO2 max
Why does VE change with training
Increase ability for gase exchange:
Greater capillarisation
Larger lung volume
Greater alveolar VE due to neural adjustments
Greater blood volume and Hb levels
Decrease sensitivity for chemoreceptors to respiratory stimulators such as CO2 and Lactate in blood
Why does VCO2 change with training
Slower production of CO2 in the conversion of pyruvate to acetyle CoA and krebs cycle
Less buffering of lactic acid into CO2 and H2O
Why does VO2 change with training
Improved metabolic/biomechanical efficiency
Primary muscle fibers for:
< AT
> AT
< AT:
SO, FOG
Fat - mix oxidation
Aerobic
> AT: FOG, FG Mix - CHO Increase lactic acid Anaerobic
Alveolar ventilation rate = VA
VA =
(Vt - Vd) x f
Trained individuals have a greater VA because
Of the slow and deep breathing patterns which cause greater Vt
Vt depth and rate of breathing in trained athletes is
Slower and deeper than untrained athletes
PO2 and PCO2 move from…
Areas of high Pp to an area of lower Pp due to diffusion
Atmospheric air PO2 : PCO2 =
159 mmHg ; 0.3 mmHg
Alveoli PO2 : PCO2 =
100 mmHg : 40 mmHg
What is the reason for a decrease in PO2 and an increase of PCO2 from the atmospheric air and air in lungs
Due to dilution of atmospheric air with the residual lung gases
Time for gas exchange at
Rest =
Exercise =
Limiting factor?
- 75 seconds
- 3 - 0.4 seconds
However it is not a limiting factor because it only takes 0.3 seconds for complete gas exchange to occur
Diffusion of O2 happens in:
Lungs: Alveoli to pulmonary capillaries
Muscle tissue: muscle capillaries to muscle tissue
Diffusion of CO2 happens in:
Lungs: Pulmonary capillaries to alveoli
Muscle tissue: muscle tissue to muscle capillaries
PO2 is greatest when and where
Before the exchange
In arteries (100)
PCO2 is greatest when and where
After the exchange
In veins (46)
When you breathe in it causes pressure to
Increase
When you breathe out it causes pressure to
Decrease
Q = P/R
Cardiac output = Pressure / resistance
What is pressure gradient indicated by
MAP (mean arterial pressure)
Best indicator of driving force of circulation***
MAP (mean arterial pressure) =
Diastolic + 1/3 of systolic - diastolic
Best indicator of driving force of circulation***
Blood flows from an area of
High pressure to an area of low pressure
From:
Left ventricle to aorta, arteries, arterioles, capillaries, venules, veins and back to right atrium
Pressure gradient in:
- Arteries
- Arterioles
- Capillaries
- Venules
- Veins
- Dramatic drop in MAP
- Increase systemic vascular tree
- Increase systemic vascular tree
- Pressure gradient low
- Pressure gradient low, contraction of skeletal muslce pushes blood back to heart
Factors that increase venous return:
Muscle pumping
Ventilatory or respiratory pumping
Vasoconstriction of veins
Pressure head
What happens in the ventilatory/respiratory pumping
Pressure in thorasic decrease
Increase in abdominal pressure beacuse of diaphragm is pulled
Blood flows from abdominal to thoracic pushing blood to right atrium
What is vasoconstriction
Reflex constriciton of veins
Drains the muscle
Controlled by CNS
What effects peripheral resistance
Viscosity
Length of circulatory pathway
Vasoconstriction/Vasodilation
What happens to peripheral resistance when:
Viscosity increases
Viscosity decreases
Length of circulation increases
Length of circulation decreases
Vasoconstriction
Vasodilation
Increases
Decreases
Increases
Decreases
Increases
Decreases
Increase in cardiac output due to
Decrease resistence and therefore a decrease viscosity and length
Increase in pressure gradient during exercise (Increase SV and HR)
Increase blood volume following training
During exercise, the %Q is distributed increases in…
Decrease in…
Skeletal muscle and skin
Kidneys, abdomin and other tissue
During exercise, the pressure decreases due to
Vasodilation of arterioles and muscle capillaries in active skeletal muscle
What is Fick equation
VO2 = Q x (A - VO2 difference)
VO2 =
Q =
A-VO2 difference =
Oxygen uptake rate
Cardiac output
Oxygen extraction
Exercise affects on components of ficks equation
Acute training:
Increases: Maximal and submaximal values due to: 1. Increase Mitochondria 2. Increase Myoglobin 3. Capillarisation 4. Oxidative enzymes and cytochrome activity
Cardiac responses from rest to submax to max workloads:
Q SV HR VE VO2 mm blood lactic acid Muscle blood flow
Q = increases
Due to HR only
SV = slight increase and then plateau
Due to HR only
HR = Same max HR in trained and untrained
Untrained just reaches max heart rate at lower workload
VE = Increase with greater than linear increase at AnT
VO2 = Increase with constant or drop at top/max
Trained individuals had less VO2 max and reaches it at heavier workload
mm Blood LA = Production of lactic acid come at higher workload
Muscle blood flow = increases
Increase EDV + Decrease ESV =
Increase SV
EDV is directly related to…
Ventricular volume and venous return
ESV is directly related to…
Contractility of myocardium and peripheral resistance
Pulmonary diffusion capacity increase from…
Rest to submax to max
What are the factors that effect Pulmonary diffusion capacity
Changes in these factors from illness will…
- Alveolar membrane - smoking
- Interstitial fluid - not enough H20
- Capillary membrane plasma - damage diabetes
- Red blood cells - anemia
Decrease PDC and endurance
Diffusion pathway (movement of O2 through tissue) can occur in…
Alveolar membrane
Interstitial fluid
Capillary membrane plasma
Red blood cells
An increase in diffusion pathway occurs due to:
Capillaries open around alveoli
Increase contact area
Increase O2 diffusion
Trained people have higher PDC because:
More capillaries open around alveoli
Size of alveoli is greater accounting for larger lung volumes
Trained individuals have higher blood volume
Trained individuals have higher hemoglobin levels
Factors determining oxygen in the blood
- Ventilation rate (VE)
- Pulmonary diffusion capacity (PDC)
- Characteristics of diffusion pathway
- Diffusion gradient and diffusion time - decreases with altitude
- Altitude above 1500m
- Characteristics of blood - RBC and Hb levels
For every increase of 1000m above 1500m, the VO2 decreases by…
10 %
Greater RBCs =
Greater Oxygen in blood
What is the greatest transports of oxygen (99%)
Hemoglobin
The PO2 determines…
The % of oxygen that is saturated with hemoglobin
Allosteric protein does what
Enhances O2 availability by two fold
Hemoglobin has binding sites for effectors that…
Can alter binding of other molecules and substrates like CO2 and H+
What is Cooperative within hemoglobin
When 1 oxygen attaches to hemoglobin it causes the second binds more easy and then the third and then the fourth even more easily.
The Hb O2 curve shifts to the right during exercise because of:
Decrease pH
Increase PCO2
Increase Temp
Increase DPG
No effect on O2 loading on Hb
Increase O2 availability to muscle tissue (unloading)
What does the curve reveal about the lungs and muscle tissue
Lungs: Hb is almost completely saturated with oxygen where PO2 is 100mmHG
Muscle tissue: PO2 10 - 30 mmHg
Hb has less affinity for O2 and therefore O2 is released from Hb so that it can diffuse into the muscle
During exercise, what effects and shifts occur
Shift to the right
Increase oxygen availability for muscle tissue
Bohr effect
Haldene effect
What is the Bohr effect
Increase PCO2 and H+ = enhanced release of oxygen from Hb
What is the Haldene effect
High PO2 in alveoli enhances the release of CO2 and H+ from Hb in the lungs
Enhances removal of Co2 and H+ from body
What is the 1st major adaptation in high altitude
Hours
DPG
Curve
Effects
After 48 hours
Increase in 2-3 DPG levels **
Shifts curve to right = increases the amount of oxygen released to muscle tissues and increases endurance performing capabilities
What is epogen
Prescription eyrthropoietin = Increases RBC and Hb levels, oxygen carrying capacity
Also increases viscosity which is not good = Heart attack
What are the exercise effects of EDV and ESV
During exercise:
EDV increases
ESV decreases
Increases SV
Exercise effects on the heart contractility
Exercise increases contractility of heart due to increase activity of the sympathetic nerveous system and frank starling law
Increase EDV puts a pre-stretch on the myocardium which results in greater force contraction
ESV is decreased and SV increases
Endurance training increases:
Blood volume and ventricular volume
Strength training increases
Ventricle wall thickness
Difference between trained and untrained at rest:
Q SV HR A-V difference VE VO2 mm LA Muscle blood flow
Q = Same at rest ** SV = Higher in trained HR = Lower in trained A-V difference = Same at rest ** VE = Lower in trained but about the same at rest VO2 = Same at rest ** mm LA = Same at rest ** Muscle blood flowSame at rest **
Difference between trained and untrained at submax and max
Q SV HR A-V difference VE VO2 mm LA Muscle blood flow
Q = Continues to increase in trained due to increase HR
SV = Higher in trained due to increase blood volume and wall thickness and increase venticular volume = increase myocardial efficancy
HR = lower in trained due to increase myocardial efficancy = less workload needed to maintain workload, increased vagus nerve domin
A-V difference = increases at submax to increase in max VO2 due to increase Q
VE = Lower in trained
VO2 = Lower due to improved cap, myoglobin and enzymes
mm LA = increases at higher workload due to higher lactate acid tolerance, breakaway at AnT