Lecture 9 Thrombolytics

Question 1

fibrin degradation pathway in vivo:

____ is converted to ____ by ____. this cleaves fibrin into fibrin degradation products such as _____

Answer 1

plasminogen, plasmin; tPa;

d-dimer

Question 2

tissue plasminogen activator is a _____

Answer 2

serine protease

Question 3

t-PA is inhibited by ____

Answer 3

PAI-1 and PAI-2

Question 4

4 thrombolytics :

Answer 4

alte-, rete-, tenecte- plase;

streptokinase

Question 5

thrombolytic therapy is indicated ASAP for _____, within 3 hours for _____, and also for direct thrombolysis of severe ____

Answer 5

MI, ischemic stroke, PE

Question 6

alteplase, reteplase, and tenecteplase are all ____

Answer 6

recombinant forms of t-PA

Question 7

in contrast to the recombinant forms of t-PA, streptokinase causes thrombolysis how?

Answer 7

forms activator complex with plasminogen

Question 8

why do you have to administer streptokinase at a high IV dose?

Answer 8

needs to be saturated against Antibodies that we make against it

Question 9

2 ways to stop bleeding caused by thrombolytics:

Answer 9

tranexamic acid, aminocaproic acid

Question 10

aminocaproic and tranexamic acid act as a ____ analog and bind the receptor on plasminogen and plasmin, blocking their action on fibrin

Answer 10

lysine