Lecture 10 Lipid Basics COPY Flashcards
phospholipid, ____, and _____ make up the surface of a lipoprotein
free cholesterol, proteins
lipoprotein core is made of ____ and _____
cholesterol esters and triglycerides
____ releases free fatty acids from lipoproteins and chylomicrons
lipoprotein lipase
lipoproteins:
____ is secreted by the liver and delivers TGs to peripheral tissue.
VLDL;
TG depleted source = IDL
lipoproteins:
____ is secreted by the liver and intestine and transports cholesterol from the periphery to the liver. this process is called ____
HDL, reverse cholesterol transport
lipoproteins:
____ deliver dietary TG’s to the peripheral tissues and liver. it is secreted by ____ cells
chylomicrons;
intestinal epithelial
lipoproteins:
LDL delivers ____ to the peripheral tissues and is the main transporter in the blood
cholesterol
apoliproteins: A1
produced in liver/intestine
which liporoteins have this? What does it do?
HDL, chylomicrons;
mediates reverse cholesterol tranpsort (activates LCAT)
apolipoproteins:
Apo B100 is produced where?
what is it found on ?
what does it do?
liver;
VLDL, IDL, LDL;
binds LDL receptor
apolipoproteins:
____ is found only in chylomicrons and is produced in the small intestine. what does it do?
ApoB48;
mediates chylomicron secretion
Apolipoproteins:
ApoE is found on what lipoproteins?
What does it do?
Produced in liver and intestine
all except LDL;
mediates chylomicron remnant uptake according to FA
his notes say reverse cholesterol transport with HDL
ApoCII is found on what lipoproteins?
What is its function?
chylomicrons, VLDL, HDL; LPL cofactor (ie binds LPL and activates it) according to FA
what lipoprotein is involved in the exogenous pathway of lipid metabolism?
chylomicrons
after cleavage by LPL, what are the 3 options for a free fatty acid?
deposit in adipose tissue; be used by skeletal or cardiac muscle; return to liver
what enzyme catylyzes esterifcation of cholesterol?
LCAT