Lecture 4 Approach to Asthma/COPD therapy

Question 1

2 general processes targeted by pharmacotherapy:

Answer 1

bronchoconstriction, inflammatory processes

Question 2

3 advantages of airway delivery:

Answer 2

fast, direct to site of action, minimizes systemic side effects

Question 3

general asthmatic treatment is organized in a ____ fashion to reduce severity and improve control

Answer 3

stepwise

Question 4

Stepwise guidelines for asthma treatment:
1. _____
2. add ____
3.

Answer 4

SABA alone as needed;
low dose corticosteroid;
low does ICS plus LABA

Question 5

asthma treatment:

4. medium dose ICS plus ____
5. high dose ICS plus LABA and ____
6. high dose ICS plus LABA plus ____

Answer 5

LABA;
omalizumab;
oral CS

Question 6

with inhalers, much of the medication is delivered to the ___ ____

Answer 6

oropharyngeal mucosa (not the best)

Question 7

with treatment of COPD, which do you add to the treatment regimen first? LABA or inhaled CS?

Answer 7

LABA

*** this is different from asthma

Question 8

COPD therapy:

1. _____ as needed
2. add ___, cardiopulmonary rehab
3. add _____
4. oxygen as needed

Answer 8

SABA;
LABA;
inhaled CS

Question 9

main problem with antihistamines:

what general category of histamines avoid this?

Answer 9

cause drowsiness;

2nd gen antihistamines

Question 10

3 first gen H1 blockers mentioned in FA:

Answer 10

diphenhydramine, dimenhydrinate, chlorphenirammine;

also hydroxyzine

Question 11

3 2nd gen anti-histamines mentioned in her notes:

Answer 11

fexofenadine, loratadine, certirzine;

Question 12

the 2nd gen antihistamines are less _____ than the first gen; thus, they don’t do what that the first gen drugs do?

Answer 12

lipophillic;

don’t cross the BBB

Question 13

2 alpha agonists used as decongestants

Answer 13

pseudoephedrine, phenylephrine

Question 14

main problem with pseudoephedrine/phenylephrine?

Answer 14

tachyphylaxis

Question 15

2 nasal steroids used to treat allergies

Answer 15

mometasone, fluticasone