Lecture 9 - The placenta Flashcards

1
Q

why does the placenta need to separate the maternal and fetal organisms?

A

because half of the embryo will contain the paternal DNA, and the mum’s immune system would reject that

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what are the time periods of the trimesters?

A

1st trimester - conception until 12 weeks
2nd trimester - 13 weeks until 24 weeks
3rd trimester -25 weeks until term (36-40 weeks)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

At what stage in the preimplantation of the embryo do cells stop being identical?

A

Morula/advance morula - the first differential division begins creation of the inner cell mass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what is the trophectoderm?

A

the outer blastomeres that form a hollow sphere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

from what does the inner cell mass form?

A

the inner blastomeres of the advanced morula

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

The ______ ____ ____ forms the rest of the ______ and contributes a bit to the _________.

A

inner cell mass, baby, placenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

The _________ are the sphere of cells surrounding the _____ ____ _____. This is going to become the __________ of the placenta.

A

tropectoderm, inner cell mass, trophoblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

when does implantation happen?

A

around day 7 after fertilisation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what orientation does the embryo implant with?

A

implants with the inner cell mass facing the uterine wall

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

PICTURE A
after orientation of the embryo, the ____________ cells differentiate into _____________ and _________________. the ____________________ secrete __________ to _______ ___ _________.

A

trophoectoderm, cytotrophoblasts, syncytiotrophoblast, syncytiotrophoblast, enzymes, degrade the endometrium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the primitive syncytium?

A

a syncytiotrophoblast

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

PICTURE B
the ________ ____________ expands, embedding the __________ into the ___________. ______ form inside the syncytium

A

primitive syncytium, blastocyst, endometrium. Lacunae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

PICTURE C
________ fuse to form larger interconnected spaces. __________ ______ ______ invade. embryo is almost _______, with ___________ beginning to _________

A

Lacunae, maternal blood vessels, buried, epithelium, heal over it.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

PICTURE D
________ is fully ________ over, and the embryo is ______.

A

epithelium, healed, buried.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

through which period is the lacunar phase?

A

days 8-12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what acts as nutrients for the embryo before maternal blood?

A

the primary syncytium grows into endometrial glands, which contain nutrients for the embryo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are trabeculae?

A

the cytotrophoblast protrusions into the lacunae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what do primary villi emerge from?

A

trabeculae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what taps the maternal blood vessels?

A

lacunae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

from day 12 to the end of term, the placenta is a?

A

villous placenta

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

how are primary villi formed?

A

cytotrophoblasts invading the trabeculae

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

once primary villi are formed, what is the lacunar space known as?

A

intervillous space

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

are there blood vessels in secondary villi?

A

no

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

how are secondary villi formed and on what day?

A

at around day 14
- extraembryonic mesenchyme invade the primary villi, forming secondary villi

24
Q

how are secondary villi formed and on what day?

A

at around day 18-20
- placental capillaries form in the villi to form tertiary villi

25
Q

what do the vessels in the villi connect to?

A

the umbilical vessels carrying blood to and from the fetus

26
Q

what statistic makes humans seem infertile as ow?

A

the fact that 60% of conceptions are lost in the first few days after conception

27
Q

what percentage of all conceptions are successful?

28
Q

what is a villous cytotrophoblast?

A

a type of trophoblast that is found mainly in the first trimester underlying the syncytiotrophoblast

29
Q

all epithelia of the placenta come from?

A

the trophectoderm

30
Q

what is a syncytiotrophoblast?

A

the largest multinucleated cell formed from the fusion of multiple villous cytotrophoblasts

31
Q

STB does not replicated, but does what instead?

A

is replaced by fusion of additional villous cytotrophoblasts

32
Q

what cells invade and remodel the spiral arteries?

A

extravillous cytotrophoblasts EVCTB

32
Q

what is an extravillous cytotrophoblast?

A

differentiated cells that migrate from 3º villi into the decidua and myometrium

33
Q

what does the 6 week placenta look like?

A

a fluffy ball about 2-3cm in size

34
Q

true or false, the fetal side of the placenta can be seen by looking at the maternal side and flipping it over

A

false, the fetal side of the placenta is the inside

35
Q

what happens to the tertiary villi on a 7-8 week placenta?

A

they regress to form the smooth chorion

36
Q

which villi regress and which villi dont?

A

regress: villi on the sides and luminal aspect
remain: villi basal to the implantation site/villi on the invading front

37
Q

what is the definitive placenta?

A

the chorion (fetal side) + the decidua basalis (maternal side)
e.g the fully developed functional placenta

38
Q

what are anchoring villi?

A

The villi that break through the syncytiotrophoblast, come into contact with the uterus and stay in contact with it.

39
Q

how do the anchoring villi contribute to establishment of fetal-maternal blood flow?

A

columns of cytotrophoblasts from the anchoring villi invade the decidua and spiral arteries int he first and second trimesters

40
Q

what are floating villi?

A

villi that do not have contact with the maternal tissues but are suspended in the intervillous space

41
Q

what do floating villi do?

A

they are responsible for exchange and barrier functions of the placenta

42
Q

what type of villi make up 99% of the villi in the placenta?

A

floating villi

43
Q

after the ____________ _________ invade the spiral arteries, the arteries are transformed into ______ ____ ______ with no ________ ____ and are now lined by ___________ _____________. trophoblast columns are advancing from the ______________ ____ into the uterine stroma

A

extravillous trophoblasts, wide bore tubes, muscular wall, endovascular trophoblasts, anchoring villi

44
Q

what happens to the spiral arteries on ~day 26

A

they close

45
Q

why do spiral arteries need to be bored out?

A

to keep them open all the time, so the baby can have a constant blood flow which is independent of mums circulatory regulating mechanisms

46
Q

a shallow trophoblast invasion of the spiral arteries can cause?

A

an undergrown baby

47
Q

the decidual reactions are ________ upon implantation

48
Q

what are the three layers of the decidua?

A
  • decidua basalis (under implantation site)
  • decidua capsularis (overlying implantation site)
  • decidua peritalis (around the remainder of the uterus)
49
Q

The _______ cells of the decidua are swollen and store glycogen

50
Q

as gestation progresses, the ________ cavity enlarges, filling the _______ cavity

A

amniotic, uterine

51
Q

which two layers of the decidua fuse to the point where you can’t tell them apart?

A

the decidua peritalis and the decidua capsularis

52
Q

what does the umbilical cord consist of?

A

whartons jelly, myofribroblasts and the spaces are filled with mucopolysaccharides
contain 2 arteries and one vein

53
Q

what is a true knot?

A

a knot in the umbilical cord, which would theoretically close the blood vessels and prevent gas exchange

54
Q

what structure of the umbilical cord prevents true knots?

A

the whartons jelly

55
Q

if a fetus died and there was a true knot, how can we find out whether or not the knot was the cause of death?

A

by examining the whartons jelly, if it is intact, then something else killed the fetus

56
Q

true or false: the placenta has lobes