Lecture 7 - Male reproduction Flashcards

1
Q

the gonads are formed from the _______ _____ which are located in the ______ ______ _______ of the embryo

A

gonadal ridges, upper lumbar region

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2
Q

the testis migrate through the ___________ into the ________

A

abdomen, scrotum

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3
Q

what is the failure of testes to descend called?

A

cryptorchidism
- 3% of males, most common defect

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4
Q

true or false, 100% of cryptorchid males are infertile

A

false

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5
Q

cryptorchidism in humans results in:

A

arrested spermatogenesis, but does not effect endocrine function

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6
Q

what structure is responsible for ensuring the descent of the testes?

A

gubernaculum

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7
Q

how does the gubernaculum drag the testis into the scrotum?

A

as the embryo and the testis grow, the gubernaculum does not, and this drags the testis down to the pelvis

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8
Q

true or false: some animals are permanently cryptorchid and are called monotremes

A

true, such as the elephant

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9
Q

what is MRKH syndrome?

A

when the female gubernaculum equivalent stunts development of the mature uterus

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10
Q

how can cryptorchidism be mimicked?

A

by warming the testis while in the scrotum 4-7ºC higher than currently

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11
Q

how are the testis/scrotum cooled?

A
  • high density of swear glands
  • spermatic artery is in close proximity to venous blood vessels, which cool the oxygenated blood coming into the testis
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12
Q

what is the perineal raphe?

A

marks the division of the testis

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13
Q

does the perineal raphe physically separate the testicles?

A

no, it is just used as an identifier to see where the separation is
- line runs from anus to ventral penis

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14
Q

what is the cremaster muscle?

A

muscle that lies under the skin of the scrotum and controls the location of the scrotum in relation to the body

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15
Q

when does the cremaster muscle contract?

A

when it is cold, to draw testis closer to the body

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16
Q

what is the tunica albuginea?

A

a tough fibrous sheath that internally covers each testicle

17
Q

each testicle is divided into ________ of which each contains the _______________ _______.

A

lobules, seminiferous tubules

18
Q

how many seminiferous tubules per testicle?
and how much length of tubule per testicle?

A

approximately 800
80cm long each
= 640m of ST per testicle

19
Q

the time taken for sperm to be produced from a germ cell is?

A

constant, the duration of spermatogenesis is fixed, for a given species and does not vary under normal conditions.

20
Q

how long does spermatogenesis take in humans?

A

64 days exactly, and a new cycle starts every 16 days

21
Q

what mechanism allows us to get a constant supply of sperm?

A

the spermatogenic wave -> like traffic at a red light. cars at the back must wait for cars at the front to go before they can

22
Q

describe the general structure of the epididymis

A

comma shaped organ
- muscular tube with a pseudostratified epithelial lining

23
Q

describe the function of the epididymis

A
  • site of sperm maturation
  • learn to swim and fertilise
24
Q

how long do sperm spend in the epididymis?

A

only about 12 days

25
Q

what are the three regions of the epididymis?

A
  • head (caput)
  • body (corpus)
  • tail (caudal)
26
Q

describe the caput of the epididymis

A

receives sperm from the rete testis.
- sperm here cannot swim or fertilise yet.
- large number of stereocilia

27
Q

what are stereocilia?

A

cilia that do not move, but absorb fluid

28
Q

describe the corpus of the epididymis

A

the convolutions decrease the the fluid content decreases

29
Q

describe the caudal of the epididymis

A
  • less stereocilia
  • muscularity increased, and moving to three layers (as fluid reduces, more muscle is required to move sperm)
30
Q

what is the degree of concentration increase of sperm by fluid reabsorption in the epididymis?

A

100 fold increase in concentration

31
Q

describe the structure of the vans deferens

A

45cm long and have three muscular layers
- inner longitudinal layer
- middle circular layer
- outer longitudinal layer

32
Q

what is the function of the vans deferens?

A

sperm storage, but must be able to move sperm well also

33
Q

describe the differences in the vas deferens at the epididymis end in comparison to the prostate end

A

the lumen is simple at the epididymal end, and at the prostate end it becomes enlarged and folded with many crypts, which allows for additional storage

34
Q

what is the name for the prostate end of the vas deferens that is large, folded and contains crypts for extra storage?

A

the ampulla

35
Q

what is the condition called where there is no vans deferens?

A

congenital absence of the vas deferens

36
Q

what are the features of CAVD?

A
  • 95% of men with cystic fibrosis have it, but also happens in normal men
  • usually bilateral, both vas are missing
  • due to genetic mutations probably
  • patients are usually infertile
37
Q

can a man do no nut november?

A

yes, their excess sperm is lost in the urine
- those bloody men are liars