Lecture 9 - Intro to Neuro Path

Question 1

Acute Neuronal Necrosis is characterized by ______ (shrinking) of the body and nucleus with ______ change in the cytoplasm. These changes are typically seen within ____ hours of anoxic insult.

Answer 1

Pyknosis

Eosinophilic

6 hours

Question 2

The Most susceptible neurons to Hypoxia/Anoxia are the ______ neurons of the _____ region of the _____.

_____ cells of the Cerebellum are also highly susceptible.

Pyramidal neurons of the _____ layers (III, IV, V) of the cerebral cortex and neurons in the basal ganglia are Somewhat susceptible.

Neurons in the ______ and ____ ____ are relatively resistant to Hypoxia/Anoxia.

Answer 2

Pyramidal neurons

CA1 region

Hippocampus

Pyramidal cells

Middle layers

Brainstem and Spinal cord

Question 3

Astrocytes that respond to injury (reactive astrocytes) undergo a process called ______ (or Gliosis) in which they Initially become _______ (termed Gemistocytes at this point), and then progress to ______ Astrocytes over a period of months –> These will stain richer in _____ .

Answer 3

Astrocytosis (or Gliosis)

Hypertrophic

Fibrillary Astrocytes

GFAP

Question 4

One of the hallmarks of Viral encephalitis is ______ nodules with ______.

Answer 4

Microglial Nodules

Neurophagia

Question 5

What shape do Microglial cell Nuclei take on when they are active/reactive?

Answer 5

Elongated