Lecture 31 - Psychosis and Antipsychotics II

Question 1

Schizophreniform disorder is defined as Schizophrenia symptoms for less than _____ months.

Brief Psychotic disorder is defined as symptoms for less than ____ month.

Answer 1

6

1

Question 2

Schizoaffective Disorder is defined as a combination of major _____ episodes AND Schizophrenia. The key here is the presence of Psychosis for at least _____ weeks in the ABSENCE of _______ episodes.

Answer 2

Mood

2 weeks

Mood

Question 3

Delusional Disorder basically falls in between Schizophreniform and Brief Psychotic in terms of timing, whereby symptoms last for greater than ____ month, but the patient’s function is NOT impaired. Delusional Disorder is more common in ______ (younger or older?) people.

Answer 3

1 month

Older

Question 4

Typical/1st gen Antipsychotics range from High Potency (High D2 blockage and low Anticholinergic effect) to Low Potency (just the opposite). What are examples of each?

Answer 4

High potency –> Haloperidol

Low potency –> Chlopromazine

Question 5

Atypical/2nd gen Antipsychotics also block D2 receptors, but act on others as well, especially ______ receptors. ______ is the most effective, but it also has the most side effects.

Answer 5

Serotonin

CLozapine

Question 6

Are Typical or Atypical antipsychotics more like to cause Parkinsonism?

Answer 6

Typical

Question 7

Chronic D2 blockade can lead to _____ ______, characterized by darting movements of the Face, Tongue, and Head.

Answer 7

Tardive Dyskinesia

Question 8

Antipsychotics can cause side effects due to blockade of:

Cholinergic –> dry mouth, constipation, etc.

_____-__ Adrenergic –> Dizziness, drowsiness, Hypotension

_______ 1 –> Weight gain and drowsiness

Others –> Metabolic Syndrome (Atypical more than Typical), _____ Prolongation, Seizures Only in patients with seizure disorders), and Rashes

Answer 8

Alpha-1 Adrenergic

Histamine 1

QTc Prolongation

Question 9

________ _______ Syndrome can be caused by Antipsychotics, and it is a life-threatening emergency. Remember the presentation with the acronym FEVER (Fever, Encephalopathy, Vital sign instability, Elevated CPK, Rigidity)

Answer 9

Neuroleptic Malignant Disorder

Question 10

Agranulocytosis can be caused by ______ (Atypical Antipsychotic with the most side effects).

Answer 10

Clozapine

Question 11

_______ is an Atypical that does not have an effect on Serotonin 2A receptors like the other Atypicals, but it acts as a D2 partial Agonist.

Answer 11

Aripiprazole

Question 12

Atypical antipsychotics are better suited to treating ______ (Positive or Negative?) Symptoms.

Answer 12

Negative (e.g. Social withdrawal)