Lecture 9: Development and Survival of Lymphocytes Flashcards
A multipotent ___________ generates all cells of the immune system
hematopoetic stem cell
T-cell progenitors originate in _____, but all the important events in development occur in _____
the bone marrow, the thymus
T-cells undergo development in ______ and migrate to the _______ where they are activated by _______
the thymus, peripheral lymphoid, foreign antigens
T-cell precursor rearranges its T-cell genes in _______
the thymus
Immature T cells that recognize ______ receive signal for ______
self MHC, survival
Those that interact strongly with self-antigen are removed from the _____
repetoire
Mature T-cells encounter _____ in the peripheral lymphoid organs and are activated
foreign antigens
Activated T cells proliterate and eliminate ____
infection
T-cell progenitors develop in _____ and migrate to _____
the bone marrow, thymus
_____ and ______ selection occur in the thymus
Positive and negative
T-cell precursors proliferate extensively in _____, but most ____
thymus, die there
The thymus is critical for _______ derived cells into T cells
the maturation of bone marrow
