Lecture 9 and 10 - causes and risk factors Flashcards
Set point theory
Biological: bodies resist marked variation playing a role
Genetic contribution of AN (research)
Strober (2002) - EDs 3x more common among relatives of AN and BN patients comapred to relative controls - some transmissibility
How is genetic influence mediated?
via the determination of…
- body weight/shape/size
- brain chemistry
- personality traits
Neurotransmitter dysfunctions:
Seretonin: AN have low levels of 5HT metabolites (specific abnormalities not identified yet)
Dopamine: hyper - sensitivity of the DA system
Neurotransmitter dysfunctions research
Kaye et al 2009 - In AN dieting reduces eating, leads to weight loss, leads to changes in neurotransmitter
puberty and role of sex hormones
- arise from psychological effects (dystatisfcation w body etc)
- before puberty 0% genetic influences but genetic factors influenced 50% after puberty
- Oestradiol (ovarian hormones) may activate genetic risk of eating disorder
Role of leptin and grehlin
Leptin is satiety hormone and grehlin is hunger hormone - disrupted in AN patients
ABA model (activity based anorexia)
Rodent studies show caloric restriction combined with access to running wheel leads to rapid increase in loco - motor activity - reduce food intake and eventually death
Research: ABA - hyperactivity in AN
40-80% AN patient’s excessive levels of activity to motor restlessness - deliberate calorie-burning weight reduction strategy, coping strategy to suppress neg states and form of thermoregulatory behaviour (Carrera et al 2012 warming is beneficial treatment)
Individual risk factors (8)
- Gender and age
- Negative body image
- Internalization of thin ideal
- Perfectionism
- Neurocognitive impairments
- Dieting
- Negatively emotionally
- Childhood sexual abuse (debateable)
Reserach: Internalization of thin ideal
Women rate their own body shape as heavier than their ideal and what they think is attractive (fallon and rozin 1985)
neurocognitive impairments
difficulties may be an intermediate phenotype triggered by a specific neurocognitive profile - poor set shifting, weak central coherence
Research: neurocognitive impairments
Lang et al 2015 - no diff in IQ but AN showed more errors on WCST and lower styles on central coherence scores (inflexible thinking etc)
Research: social and emotion processing
Kanakam et al 2013 - disordered eating is a maladaptive strategy to regulate emotions which is reinforced with the temporary reduction of anxiety - twins with AN have difficulty w emotion recognition and stronger attentional bias to social threat
Sociocultural: family characteristics of AN
- limited tolerance of disharmony, tension or poor conflict resolution skills
- propriety and rule-mindedness
- parental over - direction of child, discouragement
- preoccupations with thinness, dieting etc