Lecture 9

Question 1

what do type I interferons do?

Answer 1

induce resistance to viral replication in all cells - including MHCI expression and antigen presentation in all cells, activate dendritic cells and macrophages
activate NK cells
induce chemokines

Question 2

what do type II interferons do?

Answer 2

also antiviral
immunregulatory 
anti-tumour properties
NK cell activity 
made by T helper, cytotoxic T cells and NK cells

Question 3

what is the role of natural killer cells and how do they work?

Answer 3

innate cells
they kill virally injected host cells or some tumour cells
can recognise changes in levels of MHC I on the cell surface
contain enzymes (e.g. granzymes and perforin) which they secrete to induce apoptosis in the infected cells

Question 4

what is ADCC?

Answer 4

antibody - dependent cell - mediated cytotoxicity

Question 5

what is the difference between a TH1 response and TH2 response?

Answer 5

have different subsets of TH cells involved

TH1 relies on T0