Lecture 9&10: Drugs

Question 1

beta-lactams

Answer 1

• disrupt bacterial cell walls by binding to transpeptidase

Question 2

cephalosporins

Answer 2

• a type of beta-lactam

Question 3

Carbapenems & monobactams

Answer 3

• types of beta-lactams

Question 4

lipopeptide

Answer 4

• echinocandins, disrupt fungal cell wall

Question 5

polypeptide (bacitracin & polymxin)

Answer 5

• inhibits dephosphorylation of carrier protein (bactoprenol)

Question 6

isoniazide

Answer 6

• D-alanine analogue disrupting cell wall

Question 7

aminoglycosides

Answer 7

• inhibits 30s ribosomal subunit (codon misreading) -> inhibit protein synthesis

Question 8

tetracyclines

Answer 8

• inhibits 30s ribosomal subunit (prevents binding of aminoacyl tRNA to A site) -> inhibit protein synthesis

Question 9

CAT

Answer 9

• inhibits 50s ribsomal subunit

Question 10

macrolides

Answer 10

• inhibits 50s ribsomal subunit

Question 11

lincosamides

Answer 11

• inhibits 50s ribsomal subunit

Question 12

streptogramins

Answer 12

• inhibits 50s ribsomal subunit

Question 13

Oxazolidinones

Answer 13

• 50s ribosome inhibitor

Question 14

quinolones & fluoroquinoloines

Answer 14

• prevents unwinding of DNA -> inhibit DNA synthesis

Question 15

rifampin

Answer 15

• inhibits RNA synthesis

Question 16

metronidazole

Answer 16

• inhibits DNA synthesis

Question 17

sulfonamides

Answer 17

• inhibits bacterial metabolism

Question 18

trimethoprim

Answer 18

• inhibits DHR

Question 19

beta-lactamase; inhibitors

Answer 19

• clavulinic acid, sulbactam, tazobactam

Question 20

Agents killing spores

Answer 20

• aldehydes, H202, chlorine

Question 21

Extended spectrum antibiotic

Answer 21

• piperacillin

Question 22

Bacitracin

Answer 22

• inhibits dephosphorylation of carrier protein (bactoprenol)

Question 23

beta-propriolactone

Answer 23

• alkylating agent