Lecture 9/10 Flashcards
Menopause
What is the average age to start menopause ?
45-55 yo
When do we say that a women entered menopause ?
backwards diagnosis
1 year since the period has stopped
What is the period range of perimenopause ?
when the pt has the symptoms to one year after the period stopped
What is the MAIN difference between early menopause and premature menopause ?
early –> < 45yo
premature < 40 yo
What are the effect of menopause on ovarian function ?
decrease in number and function of the follicles
reduced release of FSH and LH
what are the effect of menopause on menstrual cycles?
menstrual irregularity
What is the main process of estrogen levels in menopause ?
Androstenedione –> body Fat –> E1 ( estrone) –> Estradiol E2
What is the ratio of estradiol to estrone before menopause ?
Estradiol : Estrone (4:1)
What type of estrogen receptors found on uterus and breast ?
Alpha
What are the estrogen receptors on blood vessels, lungs and heart ?
Beta
What happens to hormones in menopause ?
Post menopause
Low estrogen ( greatest drop) + progesterone
High FSH/LH
Where are testosterone made from ?
25% ovaries
25% adrenals
50% conversion from androstenedione
What is the main cause of decline in menopause ?
Aging and less due to menopause
Why can we not use FSH levels to diagnose in perimenopause ?
FSH fluctuate all the time
What is the symptoms for menopause ?
Vasomotor Symptoms
Mood Symptoms
Insomnia
Concentration
Ureogenital Ageing
