Lecture 12 Flashcards
PCOS
What is the pathophysio of PCOS ?
dysfunction of the ovulation, menstrual cycle
hyperandrogenism
polycystic ovaries
insulin resistance
What are the theories for PCOS ?
altered GnRH secretion –> high LH in follicular phase
high androgenic from dystegulated levels from the ovaries/adrenal gland
What causes of cysts in ovaries?
dysfunction of ovaries to immature follicles –> less ovulation
Why do women with PCOS have more risk of endomentrial cancer ?
Less progesterone from the abnormal ovulation
more production of estrogen : from testosterone and adipose tissues
What are the metabolic abnormalities of PCOS ?
diabetes
insulin resistance
HTTN
obesity
high TG and low HDL
What is the diagnosis for PCOS ?
2 criteria :
- presence of hyperandrogenism ( clinical or bio)
- ovulatory dysfunction
- polycystic ovaries
Which of the androgenic symptoms is not common in PCOS ?
deep voice and clitoromegaly
How is the rate for hirsutism ?
slow rate
What labs should we look in PCOS?
testosterone
TSH
LH, FSH, estradiol
progesterone* hard
prolactin ( r/o tumour)
DHEAS ( r/o adrenal tumour)
What happens to AMH levels in PCOS ?
hormone released from developing follicles
can be high in PCOS due to multiple follicles developed at one time
What are the benefit of using metformin ?
reduce insulin resistance , BG levles
improve lipid panel
induce ovulation
What NHP can be used for irregular menstruals ?
Inositol
What are the benefits from
