Lecture 9&10 Flashcards
adaptive immunity is triggered by capturing and presenting of foreign materials to cells that can recognize it, the cells that recognize are called
APCs (antigen processing cells)
list the 3 main APCs
dendritic cells (MOST IMPORTANT)
macrophages
B-cells
only ___________ cells can activate naïve and trigger a ____________________
dendritic cells
primary immune response
APCs capture foreign microbes or their products or their products and process large proteins by breaking them into peptides and ________ on their surfaces attached to specialized antigen-presenting structures called ___________________
presenting
Major Histocompatibility Complex (MHCs)
B cells and macrophages present antigen to ______________
memory T helper cells
secondary immune
Dendritic cells are present primarily in _____________ and _____________
epithelial tissues
lymphoid organs
3 major functions of dendritic cells
- serve as sentinel cells– activate innate defenses
- process exogenous antigens- initiate adaptive immune system
- regulate adaptive immunity – release cytokines based on pathogen type
DC cells take up things like dead microorganisms, soluble antigens, and ________________
antigen released by dead cells
langerhans cells
present in skin
looking for foreign particles
follicular dendritic cells are different from other DC in that they:
dont migrate
are located in lymphoid follicles (B-cell area)
lack MHC 2 molecules on their surface
carry many complement and Fc receptors
what do follicular dendritic cells do
can retain antigens for many weeks
present antigen to B-cells
DON’T PROCESS ANTIGEN
immune complexes for spherical bodies on the dendrites
iccosomes
iccosomes break off the dendrites and attach to
B-cells
when DCs stimulate T helper cells they provide three signals.
what happens in the first signal
when DCs stimulate T helper cells they provide three signals.
what happens in the second signal
