Lecture 8c ! Flashcards
what is the central dogma
DNA to RNA to Protein
what does transcription end in
a complementary mRNA that is a code for proteins
where does transcription happen
nucleus
what Is a gene composed of ? (4)
Promoter
Regulatory sequences
Transcribed region
Terminator
what is the TATA box?
promoter region that indicates where binding of RNA polymerase begins (the site of transcription)
what recruits RNA polymerase to the promoter region
Transcription factors
which direction does RNA synthesize in
5’ to 3’
what is an exon
coding portion of a gene
what is an intron
non coding portion of a gene that is not included in RNA transcript
what is RNA splicing and what does it form
the removal of introns and joining of exons in RNA, forming a mRNA molecule with a continuous coding sequence
why is the non template strand called the coding strand
because it corresponds to the same sequence as the mRNA that will contain the codon sequence necessary to build proteins
what direction does the template strand run in?
3’ to 5’
what is a base pair substitution mutation?
the replacement of one nucleotide and its partner in the complementary DNA strand with another pair of nucleotides
what is a missense mutation
a base pair substitution mutation in which a single nucleotide change results in a codon that codes for a different amino acid
what is a silent mutation
change in DNA codon does not result in a change in amino acid specifically
