Lecture 8 - Synaptic Disorders

Question 1

Lambert Eaton (LAM) vs Myasthenia Gravis (MG):
which is more common?
auto antibodies to pre-synaptic receptor?
auto antibodies to post-synaptic receptor?
AB’s to ACH receptor?
AB’s to Calcium channel?

Answer 1

MG;
LAM;
MG;
MG;
LAM

Question 2

LAM vs MG:
ptosis, diplopia common =
proximal muscle weakness = 
autonomic symptoms = 
improves with muscle use =
worsens with muscle use =

Answer 2

MG;
LAM;
LAM;
LAM;
MG

Question 3

LAM vs MG:
associated with small cell lung cancer =
associated with thymoma and thymic hyperplasia -=

Answer 3

LAM, MG

Question 4

congenital myasthenic syndrome:
can be due to inadequate number of ______ for release, especially with sustained presynaptic activity;
can be due to reduction in size of _____

Answer 4

synaptic vesicles (impairment in endocytosis)

individual quanta released (ie less Ach per vesicle)

Question 5

what 2 toxins cleave SNARE proteins?

this prevents ______ ____ and release of NT

Answer 5

tetanospasmin, botulinim;

vesicle fusion

Question 6

tetanus:

blocks release of ______ from ____ Cells of spinal cord. –>increased or decreased excitation?

Answer 6

GABA, glycine;
renshaw (interneurons)

increased

Question 7

botulism inhibits release of _____ at the ____.

increased or decreased excitation?

Answer 7

Ach;
NMJ;
decreased

Question 8

____ is found in the venom of black widow spiders. it triggers massive ____ _____

Answer 8

alpha-latrotoxin;

Ca-independent exocytosis

Question 9

tick paralysis is due to impaired release of _____

Answer 9

Ach

Question 10

curare and bungarotoxin both bind to ______, causing paralysis. which is reversible and which is irreversible?

Answer 10

Ach receptor;
bungaro = irreversible;
curare = reversible

Question 11

what do you use to treat myasthenia gravis, typically?

Answer 11

AchE inhibitors