Lecture 7 - Neuropathology/Motor Neuron Disease

Question 1

where are the cell bodies located for …
peripheral motor neurons?
peripheral sensory fibers?

Answer 1

anterior horn;

DRG

Question 2

nerve fiber types:

which are the largest, fastest conducting and are myelinated?

Answer 2

A fibers

Question 3

nerve fiber types:
A-delta fibers are for _____;
A ____ fibers are for motor, touch, and proproception;
A ____ fibers are for motor to muscle spindles

Answer 3

pain and temperature;
Alpha;
gamma

Question 4

Beta fibers are medium sized fibers that are myelinated or unmyelinated?
whats their function?

Answer 4

myelinated;

preganglionic autonomic efferent

Question 5

type C fibers:
small or large?
fast or slow?
myelinated or unmyelinated?

Answer 5

small, slow, unmyelinated

Question 6

C fibers:

involved with ____ pain and _____

Answer 6

thermal;

post-ganglionic autonomic

Question 7

peripheral/axonal neuropathy causes a ____ _____ loss; affects what part of the body first?

Answer 7

glove and stocking sensory;
distal extremiites

starts peripherally and moves inward

Question 8

____ neuropathy is characterized by early loss of reflexes, mild muscle atrophy, and marked distal weakness

Answer 8

demyelinating

Question 9

match the nerve with the area of entrapment:
____ nerve - carpal tunnel;
_____ nerve = guyon’s canal or cubital tunnel;
radial nerve = _____ or axilla;
____ nerve = fibular neck

Answer 9

median;
ulnar;
spiral groove;
peroneal

Question 10

what 2 nerves can be compressed at the inguinal ligament?

Answer 10

femoral, lateral femoral cutaneous

Question 11

Nerve Conduction Velocity testing is most useful for _____ to verify _____

Answer 11

mononeuropathies;

location of entrapment

Question 12

_____ may be used to help differentiate between axonal and demyelinating neuropathies. in _____ neuropathy, there is diminished amplitude of potentials distally

Answer 12

electromyography (EMG);

axonal

Question 13

upper (UMN) or lower (LMN) neuron lesion:
atrophy = \_\_\_\_
fasiculations = \_\_\_\_\_
hyperreflexia = \_\_\_\_\_
positive babinski = \_\_\_\_\_ 
clasp knife spasticity = \_\_\_\_\_\_

Answer 13

LMN;
LMN;
UMN;
UMN;
UMN;

Question 14

ALS:
UMN or LMN lesions?
sensory lesions?

Answer 14

both;

none

Question 15

ALS:
can be caused by a defect in _____ –> damage to neurons via _____:
treatment = _____ (prolongs life somewhat)

Answer 15

superoxide dismutase;
free radicals;
riluzole

Question 16

ALS is characterized symmetric or assymetric symptoms?

Primary lateral sclerosis is characterized by _____ weakness, stiffness, and hyper-relexia

Answer 16

assymetric;

bilateral

Question 17

spinal muscular atrophy:
adults or kids?
life span?

Answer 17

kids;
short;

characterized by weakness, atrophy,

Question 18

poliomyelitis:
_____ transmission of virus.
destruction of cells where?
LMN or UMN?q

Answer 18

fecal oral;
anterior horn;
LMN symptoms only

Question 19

polio:
characterized by symmetric or assymetric weakness?
clasically causes ____ fasiculations;
death by _____

Answer 19

asymmetric;
tongue
respiratory failure (if involve resp muscles)