Lecture 6 - Seizures (also see pharm deck anticonvulsants)

Question 1

the most common type of seizure originates where? symptoms?

Answer 1

medial temporal lobe (hippocampus, amygdala);

confusion, memory loss, automatic behavior

Question 2

a ____ starts the seizure. this is followed by a period of ____

Answer 2

paroxysmal depolarization shift (PDS);

hyperpolarization

Question 3

PDS results primarily from activation of excitatory ___ mediated channels such as ___ and _____

Answer 3

glutamate;

AMPA, NMDA

Question 4

the hyperpolarization following the PDS is due to opening of ____ Dependent ____ channels, mainly.

Answer 4

calcium dependent K channels;

GABA also involved

Question 5

____ ____ is when a seizure spreads to adjacent cortical areas.

Answer 5

jacksonion march

Question 6

generalized seizures typically begin in subcortical areas such as the ____-. contributing to hyperexcitability are ____ ____ channels that open when a cell is depolarized

Answer 6

thalamus;

T-type calcium