Lecture 8 practise questions

Question 1

what is EIB

Answer 1

transient narrowing of the airways in association with physical activity

Question 2

Explain why elite endurance athletes may be susceptible to the development of exercise-induced bronchoconstriction (EIB) (3 marks)

Answer 2

Chronic high ventilation in noxious environments

Airway injury-recycling, airway inflammation and structural airway remodelling

Concept supported by higher prevalence in elite swimmers and cold-air athletes

Question 3

Describe the application and difference between direct and indirect bronchoprovocation challenges (3 marks)

Answer 3

Bronchoprovocation challenges are used in clinical practice for the diagnosis of asthma and exercise-induced bronchoconstriction (EIB)

Direct challenges act directly on airway smooth muscle independent of inflammation

Indirect challenges cause inflammatory cells to release mediators to provoke airway smooth muscle constriction