lecture 8 - immunodeficiencies cont (9/9)

Question 1

(FPT)

1. what are foal reasons?

Answer 1

1. (failure to suckle/absorb) such as

congenital abnormalities

postpartum weakness

traumatic injury

dec ability to absorb Ig

Question 2

1. what is the gold standard for measuring igG?

why isn’t it used so much?

2. what tests are used more often?

why?

results reported how?

3. what is considered adequate conc?

partial FPT?

complete FPT?

Answer 2

1. radial immunodiffusion

expensive and time-consuming (24 hrs)

2. Semiquantitative ELISA-based tests

result given in minutes

as a range

3. > 800 mg/dL

400-800 mg/dL

< 400

Question 3

1. does serum total proteins or plasma protein an accurate indicator of colostrum/antibody absorption in foals?
2. is colostral dervied GGT useful?

Answer 3

1. NO
2. NO

Question 4

1. for foals > 12 hours - what is the most reliable method for achieving adequate igG levels?
2. is commercial plasma better or worse than non?

Answer 4

1. plasma IV (1-2 L)
2. better

Question 5

(plasma administration)

to reduce risk of adverse rxns… do what

1. ?

Answer 5

1. flunixin meglumide

take pretreatment TPR

Question 6

(prevention of FPT)

1. monitor mares for what?
2. evaluate colostrum quality
3. make sure foal gets how much quality colostrum?
4. screen all foals for IgG levels when?
5. test igG in sick foals asap
6. free colostrum - how long is it good for?

Answer 6

1. premature lactation
2. 2L
3. 24-36 hours
4. 1 year