lecture 7 - intro to immunodeficiences (9/9)

Question 1

(adaptive immunity)

1. what is humoral immunity?
2. what is cell-mediated immunity?

Answer 1

1. B-lymphocytes in blood and tissue, plasma cells, immunoglobin
2. T-lymphocytes in blood and lymphoid tissue

Question 2

1. what is the difference between a 1° and °2 immunodeficiency?

Answer 2

1. primary is genetic

secondary is acquired (most LA are secondary)

Question 3

1-7. what seven signs should make you suspect immunodeficiency?

Answer 3

1. infections in first week of life
2. recurrent infections
3. infection with normally non-path bac
4. isolation of rare organisms
5. infection after modified live
6. no sero response to vx
7. persistent lymphopenia/leukocytosis

Question 4

(failure of passive transfer)

1. are foals immunocompetent?
2. is equine placenta permeable to antibodies?

this means what?

3. so how does foal get antibodies?

Answer 4

1. yes - but are immunologically naive
2. no

newborn foals are almost completely agammaglobulinemic

3. colostrum you fucking moron

Question 5

(colostrum)

1. what is the dominant immunoglobulin in colostrum?
2. what immunoglobulins are present in colostrum?

what two are absorbed?

3. how long for milk to replace colostrum?

what Ig is dominant in milk?

Answer 5

1. IgG
2. IgG, IgM, IgA

IgG, IgM

(most IgA remains in gut lumen)

3. 24 hours

IgA

Question 6

(Absorption of Antibodies)

1. Ig binds what to transfer into circulation?
2. absorption is most efficient when?
3. when is absorptive capacity lost?

Answer 6

1. specialized enterocytes
2. first 6 hours of life
3. 24 hours

Question 7

1-4. what are four reasons for FPT (due to the mare)

Answer 7

1. colostrum leakage before parturition
2. poor quality colostrum
3. rejection of foal
4. death of the mare