Lecture 8 - Generation of Antibody Flashcards
What cells make Antibody?
By plasma cells
Where do plasma cells originate from?
They differentiate from B cells
What adaptations of a plasma cells allow it to perform its job efficiently?
have lots of Rough endoplasmic reticulum and Golgi apparatus
What happens to B-cells that interact strongly with self-antigens?
They are eliminated in the bone marrow before they mature
What happens to B-cells once they are activated?
They proliferate and become plasma cells or memory cells
What two signals do B-cells need to become activated? [2]
- Recognition by antigen specific Ig molecule
- T-cell dependent stimulation
Where do B-cells meet antigens?
Lymph nodes
Where do activated B-cells move to in the lymph node?
Towards the paracortex/cortex border
How does a B-cell process antigens?
Presents them on its surface in a MHC class II molecule
Which antibody is made first by plasma cells?
IgM
How do plasma cells make other types of antibody?
They undergo class switching
Where do activated B-cells and Tfh cells move after some time?
To regions of the lymph node called primary follicles
What is the purpose of Follicular dendritic cells?
- They form networks throughout the primary follicle
- They hold antigen/antibody complexes in nodules called iccosomes
The follicular dendritic cells promote the formation of iccosomes into […].
Germinal centres
What do B-cells do once they are inside the germinal centres?
They start to proliferate
