Lecture 5 - Dendritic cells Flashcards
What is the role of dendritic cells?
They are an antigen presenting cell (APC) that are best at activating and programming naive T cells
What are the three types of dendritic cells? [3]
- Conventional DCs
- Plasmacytoid DCs
- Inflammatory DCs
What are the unique functions of Inestinal Dendritic cells? [2]
- They can drive tolerance to oral antigen from food and commensal bacteria
- Can induce regulatory T cells to promote tolerance to antigens
Where do immature Dendritic cells migrate to?
To tissue from bone marrow
What are in the endocytic vesicles in Dendritic cells?
- MHC II
- Lysosomal proteins
What is the first step for Pathogen Induced Maturation of Dendritic cells?
DCs capture antigens via phagocytic receptors
What are the different routes that antigens are present by Dendritic cells? [5]
- Receptor-mediated phagocytosis
- Macro-pinocytosis
- Viral infection
- Cross-presentation after uptake
- Transfer between dendritic cells
What is the second step for Pathogen Induced Maturation of Dendritic cells?
A response to the pathogen is activated via pattern recognition receptors (LICENSING)
What is the final step for Pathogen Induced Maturation of Dendritic cells?
Toll-like receptor signalling alters Dendritic cells chemokine receptor expression
What signal is expressed by mature dendritic cells that cause them to migrate to lymph nodes?
CCR7
True or False? A mature dendritic cell takes up less antigen.
True
What adaptations allow a mature dendritic cell to attract naive T cells? [2]
- High expression of adhesion molecules
- Secretion of CCL18
How do mature dendritic cells activate T cell?
- By presenting antigens to them
- This activates any antigen specific t cells to divide and enter circulation
What does cross-presentation allow for?
Exogenous proteins to be presented by MHC I
