Lecture 8 Flashcards
1st law of thermodynamics –
Energy cannot be created or destroyed
2nd law of thermodynamics –
All energy transformations are inefficient because every reaction loses some energy to the surroundings as heat
Anabolism –
reactions that build things
Catabolism –
reactions that degrade things
If delta G is negative the reaction is
Exergonic
If delta G is positive the reaction is
Endergonic
Delta G=
∆H-T∆S
The difference between AMP, ADP, and ATP is
how many phosphate groups they have
Enzymes essentially
lower activation energy
Where do irreversibly inhibitors bind?
bonds covalently to side chains of the enzyme, permanently disables the enzyme
Reversible inhibitors bond:
non covalently to enzyme
Non-competitive inhibitors
Bind to the enzyme away from the active site and alter the shape of the active site, often function as metabolic regulators
Competitive inhibitors
Compete with the natural substrate for binding sites (concentration dependent)