Lecture 7 - Virology part 1 Flashcards

1
Q

why cant virus replivat alone

A

doesnt have al the[rotein dneeded for preploication

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2
Q

what does obligate intracelular parasite mean

A

goes indode cells

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3
Q

Viron=

A

virus particle - nucleic acid and genome surrounded by a cpasid= protien

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4
Q

geome

A

dna or rna not both

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5
Q

Dna to dna

A

replication

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6
Q

dna t mrna

A

transcription

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7
Q

mrna to protein

A

tranlsation

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8
Q

rna to dna

A

reverse ranscriptade

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9
Q

how virsus can interupt mran to dna

A

ssrna looks like the mrna ribosome bnd to ssrna - make protein - pos sense

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10
Q

used to classify viruses

A

baltimore claasification

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11
Q

railed phage

A

ds dna

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12
Q

flue

A

ssrna neg sense

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13
Q

hiv

A

ssrna pos sense w/ rna intermediate

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14
Q

in virsu dna or rna surroinded by protein coat

A

capsid

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15
Q

envolpe may made out of

A

lipid bilayer from host membrance

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16
Q

thre shapes of virus

A

icosahedral- ball
helical
complex- phage

17
Q

iscohedral

A

b sheet and a helices

fold and form symetry- to protect genoke ithin- form capsdi

18
Q

helical virus

A

virus rna surrounded by structual subunit= capisomeres

19
Q

HIv protein bind to

A

CD4 receptor

20
Q

reverse transcriptase used to

A

expres gene to genome

21
Q

bacteriophage evolved to

A

inject genokme inot cell

22
Q

how virus replicate

A

attach pentrate uncoate biosynthesis assembly release

23
Q

what happenes in attachment phase

A

cell specific recportot bind

24
Q

penetration

A

fusion of encovoelpe

25
uncoating
releases nucleic acid
26
biosynthesis
replication adn prosuction mrna - early porteins produces for replication viral nucleic acids mrna produce late proteinf - structural for new virions
27
assembly
nucleic acids and structural proteind from viron
28
relaease lysis or budding
envolpe from cell membrance or nuclear membrane = viral encoded oroetiens
29
bacreiophages much faster replicationq no intracelularcompartments
have lytuc or lysogenic cycle - when gene comporated to host genpme
30
phage determines if lytic to klysogenic
if ideal condidiotns lytic
31
Growth curve virus replication
early nucleic acid protein coats assembly and releae
32
influenxe
8 segments each segement - gene- protein | 3 make mrna polymerase 2 1 a
33
when do mutaions occur
when rna polymerase outs in wronfnuclotide in humna proof reading abiities so les likely
34
Antigenic shift
reassoirtmnet - virus replicate with another virus | because segmented genome can get new versions of virus that immune system cant recognise
35
what is swine flu
when pig infected with an dchicken flu anf human flu an d then pig infected wiht that adb burd and human can now in fect human- cant be recognised - influenae every year
36
oritein mutate
antgenic drift
37
protein change
antigenic shift
38
HIv recptor
gp120 bind to CD4 RECPETOR ON WHITE B,ID CELLDIFFUSION MEMBRAN IN RNA RELEASED VIRUS ENX=ZYMES MAKE COPY GENOKME INOT =DNA AND DNA INCOOPERATE INTO VIRUS