Lecture 7 Quiz: T Cells

Question 1

The primal developmental organ of T cells corresponds to the:

Answer 1

the thymus is the primary developmental organ of T cells.

Question 2

During positive selection, a weak interaction between an immature T cell receptor and self MHC: a. Is favourable, as it ensures the compatibility necessary for antigen presentation. b. Results in T cell apoptosis. c. Prevents the development of autoimmunity. d. None of the above as only mature T cells undergo positive selection.

Answer 2

Is favourable, as it ensures the compatibility necessary for antigen presentation. …. D is Incorrect, positive selection occurs at the early stages of T cell development.

Question 3

During negative selection, a strong interaction between an immature T cell receptor and self-peptide: a. Is favourable, as it ensures that antigens presented in the context of MHC are recognized by T cells. b. Rescues the T cell from programmed cell death. c. Results in the T cell migrating to the periphery. d. None of the above.

Answer 3

None of the above.

Question 4

Central tolerance: a. Only occurs in the thymus b. Promotes Autoimmunity. c. Rescues T cells that recognize self-antigens. d. Also involves peripheral tolerance.

Answer 4

Central tolerance also involves peripheral tolerance.

Question 5

T cells that have alpha-beta T cell receptors: a. Do not express CD4+ or CD8+ b. Constitute 95% of T cells. c. Do not need MHC to interact with antigens. d. Are not involved in adaptive immunity.

Answer 5

Constitute 95% of T cells.

Question 6

QUESTION 6 T cells that express gamma-delta chains: a. Have “Innate like” immune features. b. Express either CD4+ or CD8+ c. Undergo extensive gene rearrangements d. Can have a wide variety of antigen specificities.

Answer 6

Have “Innate like” immune features.

Question 7

The CD3 component of the TCR complex is involved in:

Answer 7

Signal transduction via phosphorylation of ITAMs

Question 8

CD4+ T cells:

a. Recognise antigenic peptides presented in the context of MHCII.
b. Recognise antigenic peptides produced by proteasome processing.
c. Recognise MHCI on most nucleated cells.
d. Are also known as cytotoxic T cells

Answer 8

Recognise antigenic peptides presented in the context of MHCII.

Question 9

CD8 co-receptors:

a. Are expressed on approximately 65% of T cells.
b. Interact with MHCII.
c. Are expressed in approximately 35% of T cells.
d. Is a marker of T helper cells.

Answer 9

Are expressed in approximately 35% of T cells.

Question 10

A characteristic of pathogen produced superantigens is that they:

Answer 10

Induce excessive uncontrolled immunity as a defence mechanism to avoid antigen specific immune responses. ….