Lecture 4 Quiz: Antigen Presentation Flashcards
Which of the following statements is correct?
a. Antigenic shift results as a consequence of mistakes introduced during viral replication.
b. Immature DCs activate naïve T cells in lymph nodes.
c. T cells recognise Antigen-MHCII complexes and activate B cells.
d. T cells are activated when soluble native pathogenic proteins are encountered.
,T cells recognise Antigen-MHCII complexes and activate B cells.
T cells only recognise processed peptides presented by MHC proteins.
Complete this sentence. Mature dendritic cells…….. a. Show reduced surface expression of MHCII protein. b. Uptake antigens by endocytosis and macropinocytosis. c. Develop finger like projections that facilitate antigen presentation. d. Present antigens to granulocytes.
. Develop finger like projections that facilitate antigen presentation.
Select a characteristic of the adaptive immune response. a. The humoral component is dependent on T lymphocyte antibody secretion. b. The response to pathogens takes at least a few days. c. Identify a limited range of pathogen-associated molecular patterns (PAMP) by lymphocyte surface receptors. d. Have developed in vertebrates and are of low specificity.
The response to pathogens takes at least a few days.
Complete this sentence. Upon secondary exposure to a pathogen, the adaptive immune response…….. a. results in the generation of memory cells. b. lasts 1-2 weeks. c. Is weaker than the primary immune response. d. has a short lag phase that lasts a couple of days.
has a short lag phase that lasts a couple of days.
Complete this sentence. T lymphocytes develop in the……..
Thymus.
Which of the statements below is a consequence of MHCII antigen presentation?
a. Leads to the activation of CD8+ T cells.
b. Enhances macrophage activation during viral infections.
c. Enhances macrophage activation during bacterial infections.
d. None of the above.
Enhances macrophage activation during bacterial infections. — viral antigens are presented by MHCI proteins.
Complete this sentence. Major histocompatability complex type I (MHCI)………
a. presents unprocessed proteins to T cells.
b. is expressed by all nucleated cells.
c. presents peptides of 3-20 amino acids.
d. activates CD4+ T cells.
is expressed by all nucleated cells. MHCI interacts with CD8+ T cells.
NOT C: peptides presented by MHCI are of 8-10 amino acids.
Which statement(s) correctly describe antigen generation. a. Exposed peptide fragments capable of associating with the MHC binding grove. b. Results as a consequence of the exogenous pathway, cross presentation or the endogenous pathway. c. Is required for the development of adaptive immune responses. d. All of the above are correct.
a. Exposed peptide fragments capable of associating with the MHC binding grove. b. Results as a consequence of the exogenous pathway, cross presentation or the endogenous pathway. c. Is required for the development of adaptive immune responses. all above is correct
QUESTION 9 Which of the following statements correctly describes the exogenous pathway of antigen processing?
a. Enables the activation of CD4+ T cells.
b. Generates antigens from cytoplasmic pathogens.
c. Involves the generation of peptides by proteasome activity.
d. Requires the action of Transporter associated with antigen processing (TAP) to mobilise small cytosolic peptides into the ER lumen.
Enables the activation of CD4+ T cells. —- The exogenous pathway enables the activation of CD4+ cells.
NOT D this is a characteristic of the endogenous pathway.
Complete the following sentence. A genetic feature that contributes to the diversity of MHC molecules involves….
a. alleles expressed from both haplotypes.
b. one gene encodes for MHC but it has multiple functions.
c. more than 3 alleles are expressed at the one locus.
d. only one allele of each gene.
alleles expressed from both haplotypes.
NOT C! 2 alleles or less are expressed at one locus.
