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MSE-2027-0 Cell and Molecular Pathology > Lecture 7: Inflammatory Blistering (Bullous) Diseases/ Malignant epidermal tumours > Flashcards

Lecture 7: Inflammatory Blistering (Bullous) Diseases/ Malignant epidermal tumours Flashcards

1
Q

What is pemphigus?

A

A rare group of blistering autoimmune diseases that affect skin and mucous membranes. Typically in 30 to 60 year olds.

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2
Q

What makes up most pemphigus cases?

A

Pemphigus vulgaris, making up 80% of cases.

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3
Q

What is paraneoplastic pemphigus?

A

Pemphigus associated with cancers, mostly non-Hodgkin lymphoma.

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4
Q

What is the pathogenesis of pemphigus vulgaris?

A

In pemphigus vulgaris, patients have antibodies (IgG), against Dsg1 and Dsg3. This leads to blisters in deep suprabasal epidermis,

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5
Q

What is the pathogenesis of pemphigus foliaceus?

A

In pemphigus foliaceus, IgG targets Dsg3 only, this results in blisters that result in superficial, subcorneal blisters.

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6
Q

What is the pathogenesis of paraneoplastic pemphigus?

A

Arises most often in the setting of lymphoid neoplasms and is also caused by autoantibodies that recognize desmogleins or other proteins involved in intercellular adhesion.

Consequence of cancer in the body, not local presence of cancer cells.

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7
Q

What are desmogleins?

A
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8
Q

What are the symptoms of pemphigus vulgaris?

A
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9
Q

What are the symptoms of pemphigus foliaceus?

A
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10
Q

What is bullous pemphigoid?

A
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11
Q

What is the pathogenesis of bullous pemphigoid?

A
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12
Q

What are the symptoms of bullous pemphigoid?

A
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13
Q

What is dermatitis herpetiformis?

A
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14
Q

What are the symptoms of dermatitis herpetiformis?

A
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15
Q

What is basal cell carcinoma?

A
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16
Q

What is the morphology of a basal cell carcinoma?

A
17
Q

How can basal cell carcinoma be treated?

A
18
Q

What is squamous cell carcinoma?

A
19
Q

What poison can cause squamous cell carcinomas to appear (rarely)

A

Arsenic.

20
Q

What is the pathogenesis of squamous cell carcinomas?

A
21
Q

What qualifies as an invasive carcinoma?

A
22
Q

How can squamous cell carcinoma be treated?

A
23
Q

What is melanoma?

A

The most deadly form of skin cancer, because of its ability to spread rapidly to other organs.
Can also occur in oral and anogenital mucosal surfaces, oesophagus meninges, and eye.

Strongly linked to acquired mutations caused by exposure to UV radiation.

24
Q

What is the pathogenesis of melanoma

A
25
Q

What are the symptoms of melanoma?

A
26
Q

How can you differentiate melanomas from other skin cancers?

A

MSE-2027-0 Cell and Molecular Pathology (11 decks)

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