lecture 7/8 Flashcards
A fibers
myelinated
sharp first pain
mech / therm stimulated
C fibers
unmyelinated
poorly localized
mech/ther/chemical
where do A delta and C fibres synapse
posterior horn
where is first site of pain modulation
posterior horn
nociceptor specific neurons receive input from ____ and ____ they are specific for ____
C
A
pain
wide dynamic range neurons receive input from __ and __ and ___
AB fibers, C and A
interneurons receive __ input and play a role in ___
diverse
pain modulation
WDR can fire __ in ___ fashion
AP
graded
WDR and dependent on __ singling
C
T/F WDR can wind up and lead to sensitization
true
the amplification system that responds to __ fibres
wind up
C
wind up is a __ in threshold and ___ in sensitivity
reduction
increase
wind up priority ___
saliency
anterolateral system compromises fibres of ____ and ___ from SC to ___ and ___
pain / temp
brainstem / thalamus
tract that compromises only the fibres projecting from SC to thalamus
spinothalamic
medial system
affective motivational component
ouch
suffering
lateral system
discriminative localized
pain in left toe
medial system area of brain
anterior cingulate cortex
lateral system area of brain
primary somatosensory
chronic pain
chronic: inflammatory pain
neuropathic
idiopathic
example chronic inflatmmory pain
arthritis
example chronic neuropathic pain
postherpetic neuralgia
example idiopathic pain
fibromyalgia
maladaptive mechanisms
peripheral
central
peripheral maladaptive mechanisms
sensitazation over expression of receptors
central maladaptive mechanisms
wind up, changes in neurotransmitter receprots
disinhibition
central sensitization types
para
dys
hyper
allodynia
parethisia / dysesthesias
increased spontaneous activity
hyperalgesia
reduced threshold for pain
allodynia
non noxious stimuli interpreted as painful
neuropathic pain symptoms
burning shooting electrical
nociceptive pain
squeeze throbbing aching
__ and __ fibres influence gut mobility
sympathetic and parasymp.
sensory information from the gut comes from what two sources
parsympatethic fibers (physiological - full) sympathies fibers (pain)
T/F referred pain can be from visceral nerve to somatic area
true
T/F referred pain can be from somatic nerve to somatic area
T
what innervates diaphragm
phrenic
cortical areas of limbic system
cingulate gyrus
parahippcampal
uncut
subcortical structures of limbic system
amygdala
hippocampus
hippocampus respsonsibel for
memory
learning
viceral / endocrine function
emotional behaviour
types of memory
declarative / explcit
non declarative / implicit
types of declarative / explicit memory
episodic (events)
semantic (factors
Decartlive / explicit memories what brain area
hippocampus
cortical
types of non declarative implicit memories
skills
habits
emotioanl memory
brain for non declarative implicit memory
basal ganglia
cerebllum
Amy
cortical areas
Case of HM
bi lateral hippocampus lesion
loss of recent memory
intelligence not affected
____ memory system for delclartive memory
medial temporal lobe
basic papez circuit
cingulate cortex
hippocampus
mamm body
thalamaus
Amygala
emotional memories
fear
reward motivation
what important
Case of Sm
bilateral Amy lesion
absesne sense of fear
emotional attention
reflective system (involuntary / automated)
Dopamine associated with wanting or liking
wanting
addiction activation of ___
dopamine neurons from VTA