Lecture 7 Flashcards
When was the first lung transplant?
1986
What is common with people who had a lung transplant?
Reflux and aspiration
What are the lungs exposed to?
Constantly exposed to the environment and is constantly exposed to a gastroesophageal reflux and aspiration
What is chronic lung allograft dysfunction?
Where the lung allograft goes wrong - measured by lung function
What happens to the lung allograft within a year?
40% loss of lung function, scar collagen blocks the airways so no air will flow. Limits airflow to certain areas if the lung
What is BOS?
A response to injury from lung transplants
What is the pathway for BOS?
Rejection/aspiration, inflammatory cells (neutrophils), epithelial damage, airway remodelling and fixed airflow obstruction (BOS)
What are methods which measure lung function?
Biopsy and flexible fibrotic bronchoscopy
Describe a biopsy for the lungs
Take a tissues, send it to histology and a molecular analysis .
What is a bronchioalveolar lavage?
Where saline is instilled into the airway and aspirated back, gives a sample of cells from the lungs which is under threat - then can measure the lung function
What is it called if gastric reflux is found outside of the oesophagus?
Extraoesophageal reflux
What is caused when stomach contents aspirate up?
Pneumonia
What is possible during allograft surgery?
Possible vagal nerve damage
What is the vagus responsible for?
Efficient emptying of the GI tract
What is gastroparesis?
Slowing down of gastric emptying as a result of lung transplantation
