Lecture 7 Flashcards
type 1 hypersensitivity
immediate, IGE mediated, allergies (reaction to molecules from outside body), first exposure (sensitization), subsequent exposure (serious), some allergic reaction are genetically predisposed (t helper cells oversensitive)
antihistamines type 1
decreased vascular permeability and decrease bronchoconstriction
corticosteroids type 1
decrease the inflammatory response
epinephrine type 1
constricts blood cells
Type 2
cytotoxic 1: hypersensitivity b/c antibody mediated destruction of cells. Intrinsic antigen (natural made) extrinsic (manmade) antigens.
Cytotoxic 2: Membrane Attack Complex (MAC)
cytotoxic 3: phagocytosis
cytotoxic 4: ADCC NKCs recognize affected cells and release perforins and granzymes/granulosis to destroy
cytotoxic 5: antibody mediated cellular dysfunction: antibodies not meant for receptors get in the way of real antibodies so dysfunctional
REGARDS ANTIGENS COMBINING W/ IGG (IMMUNE COMPLEX) WHEREAS TYPE 2BINDS TO CELLS SURFACES
Type 3
mediated by anigen-antibody complexes REGARDS ANTIGENS COMBINING W/ IGG , THEN DNA(IMMUNE COMPLEX) WHEREAS TYPE 2BINDS TO CELLS SURFACES
DNA W/ BAD ANTIGENS FLOAT AROUND UNTIL LAND ON BASEMENT MEMBRANES OF VASCULATURE. NEUTRAPHILS UNSUUCESSFULY GRANSULATE ALL OVER IT, CAUSING VASCULAR IRRITATION.
EX: LUPUS
Type 2
- Five mechanisms:
– Cell is destroyed by antibodies and complement
– Cell destruction through phagocytosis
– Soluble antigen may enter the circulation and
deposit on tissues; tissues destroyed by
complement and neutrophil granules
– Antibody-dependent cell-mediated cytotoxicity
(ADCC)
– Target cell malfunction (e.g., Graves—targets
thyroid)
TYPE 4
LIKE TYPE 1 BUT WITH MORE TISSUE DAMAGE FROM PHAGOCYTIC WBCS. ESPECIALLY SPEICFIC TO THE DERMIS/EPIDERMIS
TAKES MORE TIME THAN OTHER TYPES
DESCRIBE HUMORAL IMMUNITY (B CELLS)
TYPE 1, 2, 3 HYPERSENSITIVITIES
DESCRIBE
