Lecture 7

Question 1

type 1 hypersensitivity

Answer 1

immediate, IGE mediated, allergies (reaction to molecules from outside body), first exposure (sensitization), subsequent exposure (serious), some allergic reaction are genetically predisposed (t helper cells oversensitive)

Question 2

antihistamines type 1

Answer 2

decreased vascular permeability and decrease bronchoconstriction

Question 3

corticosteroids type 1

Answer 3

decrease the inflammatory response

Question 4

epinephrine type 1

Answer 4

constricts blood cells

Question 5

Type 2

Answer 5

cytotoxic 1: hypersensitivity b/c antibody mediated destruction of cells. Intrinsic antigen (natural made) extrinsic (manmade) antigens.

Cytotoxic 2: Membrane Attack Complex (MAC)

cytotoxic 3: phagocytosis

cytotoxic 4: ADCC NKCs recognize affected cells and release perforins and granzymes/granulosis to destroy

cytotoxic 5: antibody mediated cellular dysfunction: antibodies not meant for receptors get in the way of real antibodies so dysfunctional

REGARDS ANTIGENS COMBINING W/ IGG (IMMUNE COMPLEX) WHEREAS TYPE 2BINDS TO CELLS SURFACES

Question 6

Type 3

Answer 6

mediated by anigen-antibody complexes REGARDS ANTIGENS COMBINING W/ IGG , THEN DNA(IMMUNE COMPLEX) WHEREAS TYPE 2BINDS TO CELLS SURFACES

DNA W/ BAD ANTIGENS FLOAT AROUND UNTIL LAND ON BASEMENT MEMBRANES OF VASCULATURE. NEUTRAPHILS UNSUUCESSFULY GRANSULATE ALL OVER IT, CAUSING VASCULAR IRRITATION.

EX: LUPUS

Question 7

Type 2

Answer 7

• Five mechanisms:
  – Cell is destroyed by antibodies and complement
  – Cell destruction through phagocytosis
  – Soluble antigen may enter the circulation and
  deposit on tissues; tissues destroyed by
  complement and neutrophil granules
  – Antibody-dependent cell-mediated cytotoxicity
  (ADCC)
  – Target cell malfunction (e.g., Graves—targets
  thyroid)

Question 8

TYPE 4

Answer 8

LIKE TYPE 1 BUT WITH MORE TISSUE DAMAGE FROM PHAGOCYTIC WBCS. ESPECIALLY SPEICFIC TO THE DERMIS/EPIDERMIS

TAKES MORE TIME THAN OTHER TYPES

Question 9

DESCRIBE HUMORAL IMMUNITY (B CELLS)

Answer 9

TYPE 1, 2, 3 HYPERSENSITIVITIES

Question 10

DESCRIBE