Lecture 6B - Adaptive Immune Response to EXTRAcellular pathogens (Stiner) Flashcards
Which type of immunity (Th1/Th2) drives cell-mediated immunity?
Th1 b/c it makes IFN-gamma
Which type of immunity (Th1/Th2) drives the antibody response?
Th2
IL-4, made by Th2 cells, does what?
- class switching to IgE
- grows more Th2 cells
- inhibits Th1 cells
What do IL-10 and IL-4 do?
suppress macrophage activation?
Which two cytokines, made by Th2 immunity, supressed macrophage activation?
IL-10 and IL-4
Which cytokine, made by Th2 immunity, activates eosinophils?
IL-5
Which cytokine, made by Th2 immunity, induces more Th2 production and inhibits production of Th1 cells?
IL-4
Can naive B cells produce antibodies?
No
Do B cells need T cells to activate them all the time?
No. B cells can undergo T Cell INDEPENDENT activation.
IgM and CR2 must be engaged by antigen after B cell activation in a T-Cell _______ activation
independent
Which two molecules are necessary for a B cell to be activated in the absence of a T cell?
IgM and CR2
Which cytokines stimulate class switching from IgM to IgG?
IFN-gamma and IL-4
Give an example of ACTIVE immunization
Vaccine
Give an example of PASSIVE immunization
passive injection of preformed antibodies.
What are three types of live vaccines?
- Live attenuated
- Heterologous
- Live recombinant
Live Attenuated Vaccine
virulence has been artificially reduced. (most common from of vaccine.)
What is the most common live vaccine?
live attenuated vaccine
Heterologous vaccine
related organism of lesser virulence (smallpox vaccine)
Live recombinant vaccine
genetic engineering
