Lecture 6B - Adaptive Immune Response to EXTRAcellular pathogens (Stiner) Flashcards
Which type of immunity (Th1/Th2) drives cell-mediated immunity?
Th1 b/c it makes IFN-gamma
Which type of immunity (Th1/Th2) drives the antibody response?
Th2
IL-4, made by Th2 cells, does what?
- class switching to IgE
- grows more Th2 cells
- inhibits Th1 cells
What do IL-10 and IL-4 do?
suppress macrophage activation?
Which two cytokines, made by Th2 immunity, supressed macrophage activation?
IL-10 and IL-4
Which cytokine, made by Th2 immunity, activates eosinophils?
IL-5
Which cytokine, made by Th2 immunity, induces more Th2 production and inhibits production of Th1 cells?
IL-4
Can naive B cells produce antibodies?
No
Do B cells need T cells to activate them all the time?
No. B cells can undergo T Cell INDEPENDENT activation.
IgM and CR2 must be engaged by antigen after B cell activation in a T-Cell _______ activation
independent
Which two molecules are necessary for a B cell to be activated in the absence of a T cell?
IgM and CR2
Which cytokines stimulate class switching from IgM to IgG?
IFN-gamma and IL-4
Give an example of ACTIVE immunization
Vaccine
Give an example of PASSIVE immunization
passive injection of preformed antibodies.
What are three types of live vaccines?
- Live attenuated
- Heterologous
- Live recombinant
