Lecture 6 - Skin Cancer/Keratoses

Question 1

what is the most common skin cancer?

Answer 1

basal cell carcinoma (BCC)

Question 2

most common form of BCC is the _____ form. it has rolled border _____ and is commonly _____ or crusted

Answer 2

nodular;

telangiectasias, ulcerated

Question 3

on histology, BCC tumors are said to have ____ _____ nuclei

Answer 3

peripheral palisading

Question 4

superficial BCC is described as a _____ ______ with sheets of tumor cells and immature stroma

Answer 4

scaling plaque

Question 5

in _____ BCC, melanin is present in dermal MQs and tumor cells

Answer 5

puigmented

Question 6

in _____ BCC, there are white indurations with thin strands of tumor in a dense sclerotic stroma

Answer 6

morpheaform

Question 7

what treatment option for BCC has the highest cure rates and is the most skin sparing?

Answer 7

Mohs Micrographic Surgery;

ie sequentially larger surgeries until clear margins

Question 8

_____ can be used as topical treatment for some BCC. it is thought to induce a _____ response against the tumor

Answer 8

imiquimod;

immunological

Question 9

is BCC typically…

invasive?
metastatic?

Answer 9

yes (locally);

no

Question 10

a _______ _____ ____ is a benign skin colored papule that can look like BCC

Answer 10

benign fibrous papule

Question 11

_____ _____ is a premalignant lesion caused byy sun exposure

Answer 11

actinic keratosis

Question 12

actinic keratosis:
lesions are usually plaques or patches?
rough or smooth?
hyperkeratosis or parakeratosis?

Answer 12

plauqes,
rough,
hyperkeratosis

Question 13

what can actinic keratosis progress in to?

Answer 13

SCC

Question 14

SCC:

name 2 risk factors (besides UV light and XP)

Answer 14

immunosuppression, chronic inflammation

also HPV, tobacco/alcohol (oral cancers),

Question 15

skin cancers affecting lips, according to pathoma:

upper =
lower =

Answer 15

BCC;

SCC

Question 16

SCC:

what is seen on histology?

Answer 16

keratin pearls

Question 17

melanoma:

melanocyte tumor, which originates from ____

Answer 17

neural crest

Question 18

most common type of melanoma?

how is its prognosis?

Answer 18

superficial spreading;

good

Question 19

which type of melanoma has the worst prognosis?

characterized by early _____ growth phase

Answer 19

nodular;

vertical

Question 20

____ of the tumor correlates with risk of metastasis;

this is called “_____ thickness”

Answer 20

depth;

breslow

Question 21

the leser-trelat sign is the sudden appearance of multiple ____ ____, indicating malignancy

Answer 21

seborrhic keratoses

Question 22

topical corticosteroids:
better absorbed by normal skin or inflamed skin?
in areas of thin or thickened skin?

Answer 22

inflamed (or otherwise damaged);

thin