Lecture 6 - Skin Cancer/Keratoses Flashcards
what is the most common skin cancer?
basal cell carcinoma (BCC)
most common form of BCC is the _____ form. it has rolled border _____ and is commonly _____ or crusted
nodular;
telangiectasias, ulcerated
on histology, BCC tumors are said to have ____ _____ nuclei
peripheral palisading
superficial BCC is described as a _____ ______ with sheets of tumor cells and immature stroma
scaling plaque
in _____ BCC, melanin is present in dermal MQs and tumor cells
puigmented
in _____ BCC, there are white indurations with thin strands of tumor in a dense sclerotic stroma
morpheaform
what treatment option for BCC has the highest cure rates and is the most skin sparing?
Mohs Micrographic Surgery;
ie sequentially larger surgeries until clear margins
_____ can be used as topical treatment for some BCC. it is thought to induce a _____ response against the tumor
imiquimod;
immunological
is BCC typically…
invasive?
metastatic?
yes (locally);
no
a _______ _____ ____ is a benign skin colored papule that can look like BCC
benign fibrous papule
_____ _____ is a premalignant lesion caused byy sun exposure
actinic keratosis
actinic keratosis:
lesions are usually plaques or patches?
rough or smooth?
hyperkeratosis or parakeratosis?
plauqes,
rough,
hyperkeratosis
what can actinic keratosis progress in to?
SCC
SCC:
name 2 risk factors (besides UV light and XP)
immunosuppression, chronic inflammation
also HPV, tobacco/alcohol (oral cancers),
skin cancers affecting lips, according to pathoma:
upper =
lower =
BCC;
SCC
SCC:
what is seen on histology?
keratin pearls
melanoma:
melanocyte tumor, which originates from ____
neural crest
most common type of melanoma?
how is its prognosis?
superficial spreading;
good
which type of melanoma has the worst prognosis?
characterized by early _____ growth phase
nodular;
vertical
____ of the tumor correlates with risk of metastasis;
this is called “_____ thickness”
depth;
breslow
the leser-trelat sign is the sudden appearance of multiple ____ ____, indicating malignancy
seborrhic keratoses
topical corticosteroids:
better absorbed by normal skin or inflamed skin?
in areas of thin or thickened skin?
inflamed (or otherwise damaged);
thin
