Lecture 5 - Cutaneous Signs of Systemic Disease

Question 1

name 3 skin changes associated with SLE

Answer 1

discoid rash, malar rash, photosensitivity

Question 2

chronic discoid lupus:
erythema with ______;
scaling, follicular plugging, scarring–> _____;

usually systemic symptoms or only skin?

Answer 2

telangiectasias;
alopecia;

usually limited to skin

Question 3

dermatomyositis:

_____ rash, ____ _____ which is a rash seen on the knuckles of hands, and a heliotrope rash, which is seen where?

Answer 3

malar;
grotton papules;
periorbital

Question 4

dermatomyositis:
endomysial or perimysial inflammation?

increased risk of ______

Answer 4

perimysial;

occult malignancy

Question 5

scleroderma:
increased deposition of ______ all over the place;
diffuse form is associated with ____ antibody;
limited form is associated with _____ antibody

Answer 5

collagen;
diffuse = anti SCL70 (topoisomerase 1);
limited = centromere

Question 6

henoch-schonlein vasculitis:
classical triad =

due to _____ deposition

Answer 6

palpable purpura, arthralgias, abdominal pain;

IgA complex

Question 7

aphthous ulcers are associated with what auto-immune disease? they are said to have a ____ base with surrounding erythema

Answer 7

IBD (ie chron’s);

grayish

Question 8

behcet syndrome is characterized by aphthous ulcers, _____, and _____ -_____;
due to ____ vessel immune complex vasculitis

Answer 8

uveiits, genital ulcers;

small

Question 9

erythema nodosum:

painful, inflammatory lesions of _____ ____ usually located where?

Answer 9

subcutaneous fat;
shins

associated with sarcoid, coccidioies, histo, TB, etc

Question 10

hyper or hypothyroid?
facial myxedema = 
pretibial myxedema = 
coarse brittle hair = 
fine hair =

Answer 10

hypo;
hyper (graves);
hypo;
hyper

Question 11

_____ is hella hair due to excessive _____ production

Answer 11

hirsuitism;

androgen

Question 12

necrobiosis lipoidica:
well demarcated areas of _____ Atrophy and ulceration;
collagen degeneration with a ____ response, classical seen in ______

Answer 12

epidermal;
granulomatous;
diabetics

Question 13

xanthomas are plaques/nodules composed of lipid laden _____ in the skin;
_____ is a xanthoma in the eyelid

Answer 13

histiocytes;

xanthelasma

Question 14

what is hypertrichosis?

Answer 14

abnormal amount of hairgrowth all over body

“werewolf syndrome”

Question 15

porphyria cutanea tarda:
due to deficiency in ______;
causes blistering cutaneous lesions that worsen with ______ exposure and _____ consumption

Answer 15

uroporphyrinogen decarboxylase;

sun, alcohol

Question 16

if a question starts out with a 35 year old black women, what is the disease 95% of the time

Answer 16

sarcoidosis

Question 17

sarcoidosis:
characterized by widespread _____ _____;
____ ACE, _____ calcium

Answer 17

noncaseating granulomas;

increased, increased

Question 18

sarcoid:

_____ ____ = skin lesions on phase

Answer 18

lupus pernio

Question 19

chronic liver disease skin findings:

____ erythema, jaundice, _____ telangiectasias

Answer 19

palmar;
spider

purpura, petechiae

Question 20

pyoderma gangrenosum is associated with _______;

characterized as ____ with a rolled violaceous border

Answer 20

inflammatory bowel disease;

ulceration

Question 21

how is leukemia cutis characterized as?

Answer 21

purpuric papules and plaques

Question 22

_____ ____ is a cutaneous T-cell lymphoma characterized by skin patches/plaques

Answer 22

mycosis fungoides

Question 23

mycosis fungoides:

characterized by atypical ____ cells with “_____” nuclei and intradermal neoplastic cell aggregrates called ____ _____

Answer 23

CD4; cerebriform;

pautrier abscesses

Question 24

graft vs host disease:

what is the acute triad?

Answer 24

maculopapular rash, jaundice, diarrhea (and hepatosplenomegaly)

Question 25

what 2 transplants typically cause Graft vs Host?

Answer 25

bone marrow, liver