Lecture 6: pharyngeal Flashcards
start of bilateral pharyngeal apparatus development
4-5 weeks post fertilization
in a cranial to caudal sequence
4 pairs of temporary embryonic structures
- pharyngeal arches
- pharyngeal grooves (clefts)
- pharyngeal pouches
- pharyngeal membranes
pharyngeal arches
5 pairs of arches (5th arch almost never forms)
-mesenchymal core (paraxial mesoderm, neural crest cells, and lateral plate) lined on the outside by ectoderm and endoderm on the inside
pharyngeal grooves (clefts)
external aspect (ectoderm-epidermis)
pharyngeal pouches
4 well defined internal structures formed by outpockting of the endoderm
pharyngeal membranes
two layered structures of ectoderm and endoderm
each pharyngeal arch contains
- cartilagenous skeletal component (neural crest cell derived)
- connective tissue (neural crest cell derived) and muscle component (paraxial mesoderm)
- cranial nerve
- aortic arch artery
intramembranous bone formation
- bone develops in well vascularized mesenchyme
- absence of cartilage model
- develops flat bones of face and skull
intra cartilaginous (endochondral) bone formation
-bone formation in a pre-existing cartilage model (limb bones, weight bearing bones, and some bones of the pharyngeal apparatus)
2 prominence of the 1st pharyngeal arch
maxillary and mandibular
maxillary prominence
- cartilage: palatopterygoquadrate
- cartilage regresses and leaves no adult remnants
mandibular prominence
- large contribution to the face
- cartilage: meckel’s cartilage: leaves some adult structures
meckel’s cartilage gives rise to
-incus
-malleus
by endochondral ossification
perichondrium of meckel’s cartilage forms
- anterior ligament of the malleus
- sphenomandibular ligament
intramembranous in the maxillary prominence forms
- squamous portions of the temporal bone
- maxillary bone
- zygomatic bone
- palatine bone
- from mesenchyme derived from neural crest cells
intramembranous in the mandibular prominence forms
mandible
*from mesenchyme derived from neural crest cells
muscle components of the 1st pharyngeal arch
- 4 muscles of mastication
- tensor veli palatini and tensor tympani
- anterior belly of the digastric
- mylohyoid