Lecture 2: embryogeneses Flashcards
time it takes for a oocyte to degenerate
24 hours
time it takes for a sperm to degenerate
48 hours
structures released during ovulation
- secondary oocyte
- corona radiata
- zona pellicida
sequence of events involved in fertilization (5)
- penetration of corona radiata
- penetration of zona pellicida
- fusion of plasma membranes
- zona reaction: doesn’t allow another sperm to fertilize the oocyte - meiosis 2
- nuclei fuse –> zygote forms (~12 hours later)
cleavage division
mitotic division of the zygote
daughter cells called blastomers
2 systems for dating pregnancies
- fertilization age
- menstrual age
fetilization age
dates pregnancy from the time of fertilization, thus a six week embryo is six weeks (42 days) from the day of fertilization
menstrual age
Used by clinicians and dates the pregnancy from the woman’s last normal menstrual period (menstrual age). (divided in trimesters) The menstrual age of a human embryo is two weeks greater than the fertilization age because usually two weeks elapse between the start of the last menstrual period and fertilization
embryonic stages of development
- embryonic stage
- fetal stage
- postnatal
embryonic stage
first 8 weeks
- zygote formation
- cell division
- implantation
- organ formation
- teratogen sensitivity
fetal stage
week 9 to birth
- rapid fetal growth
- sex organ formation
- organ system function
postnatal
emotional, physical, and social growth
outer cell mass/ trophoblast
gives rise to the extra-embryonic tissues that form the placenta
inner cell mass/ embryoblast
gives rise to the embryonic cells and layers that form all of the tissues and organs of the body (intra-embryonic)
stages in human implantation
5-maturation of blastocyst
5-loss of zone pellucida
6-attachment of blastocyst to uterine epithelium
6-7- epithelial penetration
7-9-trophoblastic plate formation and invasion of uterine storm by blastocyst
what is the usual site of implantation
the posterior, superior wall of the uterus
ectopic pregnancy ?
“out of place”
happens ~ 0.25 to 1% of the time
where do most ectopic pregnancies occur?
ampulla of the uterine tube
rick factors for ectopic pregnancies
pelvic inflammatory disease, endometriosis
clinical signs for ectopic pregnancies
abnormal bleeding, abdominal pain, positive pregnancy test, intraperitoneal blood
decidua
name for endometrium after implantation
after implantation trophoblast proliferates into 2 layers
cytotropoblast layer
syncytiotropoblast
cytotropoblast layer
mitotically active inner layer of cells
syncytiotropoblast
produces human chorionic gonadotropin (hCG)- feedback to the ovary to the corpus luteum (hormones maintain the pregnancy until the placenta is fully functioning)
after implantation the cells of the embryoblast reorganize into 2 epithelial layers
epiblast layer
hypoblast layer
epiblast layer
- form a membrane that lines the amniotic cavity
- dorsal aspect of the disc
- gives rise to the embryo
hypoblast layer
- form a membrane that lines the yolk sac
- also called the primitive endoderm
- does NOT contribute to the cells developing embryo
- ventral aspect of the disc
2 cavities that form
- amniotic cavity
- yolk sac/ umbilical vesicle
amniotic cavity
• The amniotic membrane surrounds the embryo
following body folding
• Prevents mechanical injury to the fetus
• Allows normal fetal movements
• Cavity expands until fluid content reaches nearly one L by 33 weeks
• Sources of amniotic fluid:
o Amnion cells
o Maternal tissue (diffusion across chorionic plate)
o Fetal urine
extraembryonic mesoderm
forms between the yolk sac and cytotrophoblast
chorionic cavity divides the extraemrbyonic mesoderm into the
- extraembryonic somatic mesoderm
- extraembryonic splanchnic mesoderm
extraembryonic somatic mesoderm
lining cytotrophoblast and amnion
extraembryonic splanchnic mesoderm
lines the yolk sac
the chorion forms the wall of the chorionic cavity and has 3 layers
- extraembryonic somatic mesoderm
- cytotrophoblast
- syncytiotrophoblast
connecting stalk
suspends the amniotic cavity and the yolk sac in the chorionic cavity
-future umbilical cord