Lecture 6: Intro to Immunology Flashcards
This is the resistance to infectious disease
Immunity
This is a collection of cells, tissues, and molecules that mediate resistance to infections
Immune system
This is a coordinated reaction of the immune system to infectious microbes
Immune response
This is the study of the immune system
Immunology
What is the principal function of the immune system?
Defense against microbial infections
Can the immune response be a barrier to transplantation and gene therapy
Yes
B and T lymphocytes are in what system?
Adaptive immunity
In the first few hours of infection, what events occur? What about several hours/days later?
a. The innate immune system responds rapidly to viral infection
b. Then the adaptive system responds after being activated by the innate
Is the innate immune system antigen-specific?
No, recognizes PAMPs and DAMPs instead
What immune system is “nonreactive to self”?
a. Innate
b. adaptive
Do you have memory in innate immunity?
no
What immune system is highly antigen-specific?
Adaptive immune system
What cell type is required for all humoral immune responses?
B lymphocytes
What cell type is required for all cell-mediated immune responses?
T cells
Cytotoxic and Helper T cells are the mediators of what immunity?
Cell-mediated immunity
antibodies/B-cells are the mediators of what immunity?
Humoral immunity
What are the 2 major functional classes of effector T lymphocytes?
Helper T cells
Cytotoxic T lymphocytes
The responsibility of these cells is specific recognition of antigens
Lymphocytes (B and T)
This is when you ensure that distinct antigens elicit specific responses in adaptive immunity
Specificity
This is when the immune system is able to respond to a large variety of antigens
Diversity
This is when responses are optimally generated for defense against different types of microbes
Specialization
In addition to T cells, which cell types are required for initiation to all T cell-mediated immune
responses?
antigen-presenting cells
Bone marrow produces what?
B lymphocyte
Thymus produces what?
T lymphocyte
What are the stages of B and T lymphocytes?
a. Antigen recognition
b. Proliferation
c. Differentiation
T cell zone is found where?
Parafollicular cortex
B cell zone is found where?
Lymphoid follicle
After lymphocytes are activated by an antigen, B and T cells migrate
Towards each other and meet at the edge of the follicle
Does active immunity give you specification and memory?
a. Yes or both
If you get a microbial antigen (vaccine or an infection), what type of immunity will you get?
Active humoral immunity
When you administer serum (antibodies) from an immune individual to an uninfected individual,
that is what type of immunity?
Passive humoral immunity
Does passive immunity give you specification and memory?
Only specification, no memory
